VULVAR CANCER

This study tests whether a single dose of a patient's own genetically modified immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before standard treatment like chemo-radiation or surgery. About 15 adults with advanced HPV-positive cancers (e.g., cervical, …

This study looks at how well the drug T-DXd works for people with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. About 100 adults in the US will be followed to see if their tumors shrink or stop growing. The goal is to u…

This study tests whether the immunotherapy drug dostarlimab, given alone or with bevacizumab, works better than standard chemotherapy for people with recurrent gynecological clear cell carcinoma (a rare cancer of the ovary, uterus, cervix, vagina, or vulva). About 198 participant…

This study tests a new experimental drug called GI-101, given alone or with other cancer drugs (pembrolizumab or lenvatinib), in people with advanced solid tumors that have spread. The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults with canc…

This study tests a treatment called electrochemotherapy for women whose vulvar cancer has come back. It combines a chemotherapy drug (bleomycin) with short electric pulses to help the drug enter cancer cells more effectively. The goal is to shrink tumors and reduce the need for e…

This study tests whether the drug belzutifan can shrink or slow the growth of clear cell cancers of the ovary, uterus, cervix, vagina, or vulva that have come back or not gone away. About 32 adults will receive belzutifan pills and be monitored for tumor response and side effects…

This study looks at whether buying over-the-counter pain relievers or digestive aids can be an early warning sign for 10 types of cancer, including pancreatic, colon, and ovarian cancer. Researchers will compare the shopping habits of 2,900 people—some recently diagnosed with can…

This study looks at whether using a dye called indocyanine green (ICG) alone is as accurate as the usual two-method approach (ICG plus a radioactive tracer) for finding cancer that has spread to lymph nodes in early vulvar cancer. About 58 women with early-stage vulvar cancer wil…

This study tests whether using MRI to guide brachytherapy (internal radiation) for gynecologic cancers like cervical or uterine cancer can better target tumors and reduce radiation to nearby organs like the bladder and rectum. About 54 adults who are already eligible for standard…

This study tests whether Reiki, a gentle hands-on energy therapy, can reduce anxiety and pain in people receiving brachytherapy (internal radiation) for gynecologic cancers like endometrial, cervical, vaginal, or vulvar cancer. About 70 participants will be randomly assigned to r…

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecologic cancers (cervical, endometrial, ovarian, or vulvar). Researchers will track CRP levels in 120 women receiving immunotherapy plus chemo…

This study looks at whether tailoring surgery for vulvar cancer based on whether the cancer is linked to HPV or to a p53 gene change can lead to better outcomes. About 249 women with early-stage vulvar squamous cell carcinoma will have their treatment guided by these markers. The…