VAGINAL CANCER

This study tests whether a single dose of a patient's own genetically modified immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before standard treatment like chemo-radiation or surgery. About 15 adults with advanced HPV-positive cancers (e.g., cervical, …

This study tests a new immunotherapy for people with advanced HPV-related cancers (cervical, throat, anal, and others). Doctors take a patient's own immune cells, add a special receptor to help them find and attack HPV-infected cancer cells, and give them back. The goal is to shr…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive cancers that have spread and no longer respond to other treatments. About 100 people will take part, and researchers will track whether tumors shrink and how long the benefit lasts. The goal i…

This study tests a new experimental drug called GI-101, given alone or with other cancer drugs (pembrolizumab or lenvatinib), in people with advanced solid tumors that have spread. The goal is to see if the drug is safe and can shrink or control tumors. About 317 adults with canc…

This study tests whether the drug belzutifan can shrink or slow the growth of clear cell cancers of the ovary, uterus, cervix, vagina, or vulva that have come back or not gone away. About 32 adults will receive belzutifan pills and be monitored for tumor response and side effects…

This study tests whether using MRI to guide brachytherapy (internal radiation) for gynecologic cancers like cervical or uterine cancer can better target tumors and reduce radiation to nearby organs like the bladder and rectum. About 54 adults who are already eligible for standard…

This study tests whether Reiki, a gentle hands-on energy therapy, can reduce anxiety and pain in people receiving brachytherapy (internal radiation) for gynecologic cancers like endometrial, cervical, vaginal, or vulvar cancer. About 70 participants will be randomly assigned to r…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancer. Ten participants will receive brachytherapy with a personalized 3D-printed mold. Th…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…