UTERINE CERVICAL NEOPLASMS

This early-stage trial tests a drug called sigvotatug vedotin, alone or with other medicines, in people with advanced solid tumors like lung, head and neck, or breast cancer. The goal is to find a safe dose and check for side effects. About 1,000 participants will join this study…

This trial tests a new drug called UCB4594, an antibody that targets a protein (HLA-G) found on many cancer cells. The goal is to see if it helps the immune system attack tumors. It is for people with advanced solid tumors (like lung, breast, or colon cancer) that have not respon…

This study tests whether the immunotherapy drug dostarlimab, given alone or with bevacizumab, works better than standard chemotherapy for people with recurrent gynecological clear cell carcinoma (a rare cancer of the ovary, uterus, cervix, vagina, or vulva). About 198 participant…

This study tests a new drug called LY4170156 in people with advanced solid tumors, such as ovarian, lung, and breast cancers. The drug is designed to target and kill cancer cells while sparing healthy ones. The trial has two parts: first to find the safest dose, then to see how w…

This study is testing a new, low-cost screening tool for cervical cancer that uses artificial intelligence to analyze digital images of the cervix. It does not require a lab and can be used at the point of care. The goal is to see if this AI tool can accurately detect precancerou…

This study follows 250 women living with HIV in Zimbabwe who have been treated for cervical pre-cancer. Researchers want to find out how often the disease returns and which tests best predict that return. Participants will have regular check-ups and tests every six months for two…

This study looks at MRI scans from 120 women with advanced cervical cancer to see if a computer model can predict who will respond well to standard chemoradiotherapy. The goal is to identify women who might need different or stronger treatments early on. Researchers will analyze …

This study tests whether an interactive video program, paired with a community health worker, can help more African American women get screened for cervical cancer. About 288 women who are overdue for screening will be split into two groups: one gets the interactive video plus a …