UROTHELIAL CANCER

This is the first study in people testing a new drug called AVZO-103 for advanced cancers that have spread. The main goals are to find a safe dose and see if the drug can shrink tumors in adults with advanced bladder cancer or other solid tumors. The study will test the drug alon…

This study is testing a new combination of targeted cancer drugs for people with advanced bladder cancer that has spread. The goal is to find the safest and most effective doses of these drugs, which work in different ways to attack cancer cells. The trial will include people who…

This early-stage study is testing whether two new immunotherapy drugs, M7824 and PDS01ADC, can help the body's immune system fight advanced bladder, kidney, and related cancers that have spread. Researchers want to see if adding a precise, high-dose radiation treatment (SBRT) mak…

This is a first-in-human study to test the safety and early signs of effectiveness of a new drug called STRO-004 in adults with advanced solid tumors that have come back or stopped responding to other treatments. The trial will test STRO-004 alone and in combination with an exist…

This trial is testing whether a new drug combination called izalontamab brengitecan works better than standard chemotherapy for people with advanced bladder cancer that has stopped responding to immunotherapy. About 470 participants will receive either the experimental drug or ch…

This is the first human study of an experimental drug called SLV-154 for people with advanced solid tumors that have spread. The main goal is to find the highest safe dose and understand how the body processes the drug. About 70 adults with one of ten specific advanced cancers wh…

This study is for people with advanced bladder cancer that has continued to grow despite receiving a specific prior combination treatment. It will compare a new drug combination (datopotamab deruxtecan plus a platinum chemotherapy) against a standard chemotherapy combination. The…

This study is testing whether analyzing DNA and proteins in urine can help detect cancers of the bladder and kidney. Researchers will compare this new, non-invasive method to current standard procedures like cystoscopy. The goal is to develop a simpler, more comfortable way to fi…

This study aims to understand how often and how severely nerve damage occurs in patients receiving a specific combination treatment for advanced bladder cancer. Researchers will follow 80 patients at German hospitals to track side effects, quality of life changes, and how nerve d…

This study aims to collect blood, urine, saliva, and tissue samples from people with bladder/urinary tract cancer and healthy volunteers. Researchers will compare these samples to understand what genetic and cellular changes cause this cancer to develop. The goal is to identify n…

This study aims to collect real-world information on the safety and effectiveness of PADCEV, a treatment for advanced bladder cancer. It will follow about 200 adult patients in South Korea who are already prescribed this drug by their doctors as part of their standard care. Resea…

This study aims to understand the course of rare cancers in the urinary system (like bladder, kidney, and prostate cancers) by tracking patients over time. Researchers will collect medical information, blood, urine, and sometimes tumor samples from about 1,100 adults with these c…