UNRESECTABLE MALIGNANT SOLID NEOPLASM

This early-phase study tests a combination of two drugs, DS-8201a and olaparib, in people with advanced HER2-positive cancers that have spread or cannot be removed. The goal is to find the safest dose and see if the combination can shrink or stabilize tumors. About 55 adults whos…

This early-stage study tests two drugs together for people with HER2-positive stomach cancer or other solid tumors that have spread or can't be removed. The drugs, trastuzumab deruxtecan and azenosertib, aim to kill cancer cells more effectively. The main goals are to find the be…

This early-stage trial tests a new drug called MTI-301 in about 42 adults with advanced solid cancers that have spread or not responded to standard treatments. The drug blocks an enzyme (SCD1) that some cancers need to grow. The main goals are to find a safe dose and check for si…

This early-stage trial tests two experimental drugs, peposertib and tuvusertib, together in people with advanced solid tumors that have spread or cannot be removed. The main goals are to find the safest dose and understand side effects. About 66 adults whose cancer has not respon…

This early-stage trial tests the safety and best dose of combining two drugs—pidnarulex and trastuzumab deruxtecan—in people with advanced breast cancer or other solid tumors that have a protein called HER2. The study includes up to 36 adults whose cancer has spread, cannot be re…

This early-phase study tests the safety and best dose of two drugs—ZEN003694 and abemaciclib—given together to people with advanced breast cancer, NUT carcinoma, or other solid tumors that have spread or can't be removed by surgery. The goal is to see if the combination can shrin…

This early-stage trial tests the safety and best dose of a new drug (ZEN003694) combined with a standard chemotherapy (capecitabine) in adults with solid tumors that have spread or cannot be removed by surgery and have stopped responding to prior treatments. The goal is to find a…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…

This study is testing whether two drugs, ZEN003694 and talazoparib, can shrink tumors in people with advanced solid cancers that have spread or cannot be removed. The trial enrolls 88 adults whose cancer has not responded to standard treatments. Researchers will also look at how …

This early-stage trial tests a drug called novobiocin in people with advanced solid tumors that have specific DNA repair gene mutations (like BRCA). Novobiocin blocks a protein that cancer cells use to fix their damaged DNA, causing them to die. The study aims to find the safest …

This early-stage study tests a new chemotherapy drug, TR-002, in about 52 people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and check for side effects. The study also looks at whether the drug can shr…

This study screens people with advanced solid tumors to see if their cancer has specific genetic changes. Based on those results, they may be matched to a treatment trial that targets their tumor's unique genetics. The goal is to learn how well these targeted combinations work an…