TYPE2DIABETES

This study tests whether a low-fat vegan diet and nutrition classes can improve health and lower medical costs for people with type 2 diabetes. Seven hundred Blue Cross Blue Shield subscribers will follow the diet for 16 weeks. Researchers will measure changes in weight, blood su…

This study compares two common diabetes medications—SGLT2 inhibitors and GLP-1 receptor agonists—to see which is better at preventing heart attacks, strokes, kidney failure, and death in people with type 2 diabetes who also have or are at high risk for heart disease. About 6,000 …

This study tests whether a supplement called NMN can improve kidney health in people with type 2 diabetes and diabetic kidney disease. About 156 adults will take either NMN or a placebo twice daily for 6 months. The main goal is to see if NMN reduces protein in the urine, a key s…

This study tests a 6-month program combining exercise training, problem-solving skills, and community health worker support for 210 adults with type 2 diabetes, obesity, and early signs of heart trouble. Participants must have low income and live in Baltimore or Washington County…

This study tests whether giving adults at risk for type 2 diabetes free fresh produce, cooking classes, and a year-long lifestyle program can help them lose weight and control blood sugar. One hundred participants will either get the standard diabetes prevention program alone or …

This study tests if Dialectical Behavioral Therapy (DBT), which focuses on emotions and mindfulness, can help teens aged 14-17 with obesity improve their quality of life and weight management. The goal is to prevent type 2 diabetes. Participants will be randomly assigned to one o…

This study looks at whether a 12-week home-based strength training program, supported by technology and telehealth, is practical for 20 adults aged 55-80 with type 2 diabetes and mild cognitive impairment. Participants will start with supervised sessions and gradually exercise on…

This study tests whether a 6-week program of non-weight bearing exercise can help diabetic foot ulcers heal faster than standard wound care alone. Forty adults with type 2 diabetes and a foot ulcer will be randomly assigned to either exercise plus standard care or standard care o…

This study helps older adults with type 2 diabetes who take sulfonylurea drugs—which can cause dangerous low blood sugar and heart problems—switch to newer, safer medications. Researchers will give some patients a simple question sheet to start a conversation with their doctor, w…

This study tests whether taking vitamin B1 (thiamine) capsules can improve brain function and repair the blood-brain barrier in adults with type 2 diabetes. About 52 participants will have MRI scans, memory tests, and blood work over two visits, three months apart. The goal is to…

This study looks at why diabetes can damage the heart even without clogged arteries. Researchers will examine heart tissue and use advanced imaging in 500 adults with heart failure, with or without type 2 diabetes. The goal is to find early warning signs and new treatment targets…

This study tests whether offering a diabetes test right after delivery (instead of waiting 4-12 weeks) helps more women get screened. It also surveys women with a history of gestational diabetes to understand what helps or hinders heart health counseling and lifestyle changes. Ab…

This study looks at whether giving doctors a detailed geriatric assessment (including frailty and overall health) helps them choose safer and more effective diabetes treatments for patients aged 60 and older. About 220 participants will be randomly assigned to usual care or to ha…

This study looks at how SGLT2 inhibitors, a type of diabetes medicine, change energy levels in the heart and muscles. Researchers will measure key energy molecules in 71 adults with type 2 diabetes and heart failure. The goal is to understand how these drugs work, not to test a n…

This study looks at how cutting calories affects the way the liver processes amino acids, sugars, and fats in people with type 2 diabetes. Researchers want to see if weight loss helps the liver respond better to a hormone called glucagon. About 20 adults with type 2 diabetes and …

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health problems like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease…