Tricuspid regurgitation

This study tests a device called the Edwards PASCAL System, which is threaded through a blood vessel to repair a leaky tricuspid valve in the heart. It is for people with severe symptoms who are not good candidates for open-heart surgery. About 1,270 participants will be randomly…

This study tests a new device called the VDyne System, which is placed through a tube in a blood vessel to replace the tricuspid valve in the heart. It is for people with severe tricuspid regurgitation, a condition where the valve does not close properly, causing blood to leak ba…

This trial tests a new device, the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System, designed to replace the tricuspid valve in people with severe, symptomatic tricuspid regurgitation. The procedure is done through a catheter, avoiding open-heart surgery. The study…

This early study tests a new device called the Laplace TTVR System, which is designed to replace the tricuspid valve without open-heart surgery. It involves 15 people aged 60-90 with severe tricuspid regurgitation that continues despite medication. The main goal is to see if the …

This study tests a new device called DragonFly-T that clips a leaky tricuspid heart valve closed, avoiding open-heart surgery. About 236 people with severe symptoms who are too high-risk for surgery will be randomly assigned to get the clip or continue medical therapy. The goal i…

This early study is testing a new device called the DUO System, which is placed through a catheter to reduce leakage in the tricuspid valve. The study will include 15 people with severe tricuspid regurgitation who still have symptoms despite medical therapy. The main goal is to s…

This study follows 550 people who receive Abbott annuloplasty rings or bands during surgery to fix leaky mitral or tricuspid heart valves. Researchers will track survival, need for repeat surgery, and symptom improvement for five years. The goal is to confirm the devices work wel…

This study tests a new device called the Cardiovalve system to treat severe tricuspid regurgitation, a condition where a heart valve leaks. About 150 people aged 18-84 who are too high-risk for open-heart surgery will receive the valve. The goal is to see if the valve safely redu…

This study is checking how well the TriClip device works and how safe it is for people in Japan with a leaky tricuspid valve. The device is already approved for use, and this study will follow 250 patients to confirm its benefits in everyday medical practice. The main goal is to …

This study tests a new device called the VDyne System to replace the tricuspid valve in people with severe tricuspid regurgitation (a leaky heart valve). The goal is to see if the device is safe and can improve symptoms, exercise ability, and quality of life. About 30 adults with…

This study looks at whether a procedure to repair a leaky tricuspid heart valve can improve kidney function, reduce swelling, and boost physical activity in older adults. Researchers will follow 100 participants for changes in kidney health, walking ability, and daily function. T…

This early study tests a new device called the Pivot Extend in 10 adults with severe tricuspid regurgitation (a leaky heart valve) who are too high-risk for surgery. The device is threaded through a vein in the leg to the heart, where it helps the valve flaps close tightly. The g…

This early study tests a new device called the Trisol System, which replaces the tricuspid valve using a tube inserted through blood vessels, avoiding open-heart surgery. It includes 30 adults with moderate or severe tricuspid regurgitation who have symptoms like shortness of bre…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

Tricuspid regurgitation happens when the heart's tricuspid valve leaks, letting blood flow backward. Open heart surgery to fix it carries high risks, and some people are not eligible for other catheter-based repairs. This study tests the Lux-Valve Plus, a replacement valve delive…

Researchers are studying how non-invasive tools can characterize tricuspid regurgitation, a heart valve condition linked to heart failure and liver problems. The trial enrolls 450 adults with moderate or worse tricuspid regurgitation and uses a lung fluid sensor and a liver stiff…

This global registry will follow 800 patients receiving a new, less-invasive tricuspid valve replacement (TTVR) for leaky heart valves. Researchers aim to track complications like pacemaker needs and how well the valve works over time. The study does not test a new drug but gathe…

This observational study follows 1000 adults with cardiac implantable electronic devices, such as pacemakers and defibrillators, to see how these devices affect tricuspid regurgitation, a condition where the heart's tricuspid valve leaks. Researchers will use 3D echocardiography …

This study will compare two newer pacemaker technologies—left bundle branch area pacing and leadless pacing—to see how they affect heart function and the tricuspid valve. Twenty adults with certain heart block conditions will receive both types temporarily during their routine pa…

This study is for people getting a minimally invasive procedure to fix leaky heart valves. Researchers will use MRI scans to see how the heart changes shape and works better after the procedure. The goal is to learn which patients benefit most and why, helping doctors improve fut…

This study follows 200 adults who have had or will have a procedure to fix a leaky or narrowed valve in the right side of the heart. Researchers track survival, unplanned hospital stays, and heart function using blood tests and ultrasound. The goal is to learn which treatments wo…

This study involves 70 adults with severe heart valve disease who are already scheduled for a routine heart catheterization. Researchers will use special catheters to measure how well the right side of the heart works with the lungs. The goal is to see if simpler, non-invasive te…