THROMBOCYTOPENIA

This study looks at whether giving platelet transfusions only when platelet levels are very low is better for extremely premature babies (born at 23-26 weeks) than giving them at a higher threshold. About 2,400 infants will be enrolled within 48 hours of birth. The goal is to see…

This study tests if a single infusion of umbilical cord blood can safely raise platelet levels in cancer patients whose platelets dropped due to chemotherapy or other cancer drugs. About 25 people aged 12 to 65 will receive the infusion and be monitored for 28 days. The goal is t…

This program provides eltrombopag, a drug that raises platelet counts, to patients with serious or life-threatening thrombocytopenia who have no other treatment options and cannot join a clinical trial. Doctors must request the drug for individual patients who may benefit. The go…

This study is for cancer patients who have both a blood clot and low platelet counts. Researchers want to see if a specially adjusted dose of the blood thinner apixaban can safely treat the clot while causing fewer bleeding problems. About 30 participants will take the adjusted d…

This study looks at whether the drug T-DM1 can be safely given to breast cancer patients who previously had low platelet counts (thrombocytopenia) from chemotherapy. About 56 adults whose platelets have returned to normal will receive T-DM1. The goal is to see how many can avoid …

This study is testing whether giving a whole blood transfusion can improve survival in children under 5 years old who have severe malaria and very low platelet counts. The trial will enroll 132 children in areas where malaria is common. The goal is to see if this simple treatment…

This study tests whether etamsylate, a drug that helps blood clot, can prevent serious bleeding in people with very low platelet counts after a stem cell transplant. About 404 adults will receive either etamsylate or a placebo, and researchers will track who has major bleeding or…

This study tests the drug luspatercept in 50 adults with clonal cytopenias of uncertain significance (CCUS), a condition where blood cell counts are low and there is a risk of developing blood cancer. Participants receive injections every three weeks for up to 48 weeks. The goal …

This early-stage study tests a single injection of umbilical cord blood cells (XJ-MK-002) in 16 adults aged 18-75 who have low platelets from cancer therapy. The main goal is to check safety and find the best dose. Researchers will monitor side effects and platelet counts for 28 …

This study is testing whether a special blood test (MAIPA) can help doctors tell if a low platelet count is caused by an autoimmune problem. It will include 225 adults with low platelets who haven't started treatment yet. The goal is to see if the test can make diagnosis faster a…

This study looks at the best way to treat blood clots in cancer patients who also have low platelet counts, which raises bleeding risk. Researchers will compare two approaches: full-dose blood thinners with platelet transfusions, or a reduced dose without transfusions. The goal i…