Cord blood infusion aims to rescue cancer Patients' platelet counts
NCT ID NCT07441720
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single infusion of umbilical cord blood can safely raise platelet levels in cancer patients whose platelets have dropped due to chemotherapy or other cancer treatments. Researchers will enroll 25 people aged 12 to 65 and monitor their blood counts for 28 days after the infusion. The goal is to reduce the need for platelet transfusions and manage bleeding risk.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 25 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2026
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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12 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged 12 to 65 years at the time of signing the informed consent, regardless of gender. 2. Meets the diagnostic criteria for cancer treatment-induced thrombocytopenia (CTIT):Peripheral blood platelet count \< 100 × 10⁹/L; Prior definite exposure to a chemotherapy agent (or tumor-targeted therapy, immunotherapy, or other anti-tumor drugs) known to cause thrombocytopenia, with gradual improvement of thrombocytopenia-related symptoms/signs or normalization of platelet count after discontinuation of the offending drug; Presence or absence of bleeding tendency, such as petechiae, purpura, unexplained epistaxis, or even severe organ/tissue hemorrhage; 3. No significant hepatic or renal impairment: ALT and AST ≤ 2.5 × upper limit of normal (ULN), serum creatinine (Cr) and blood urea nitrogen (BUN) ≤ 1.25 × ULN; 4. Karnofsky Performance Status (KPS) score ≥ 60 (see Appendix 1), Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (see Appendix 2); 5. Estimated life expectancy of more than 3 months. Exclusion Criteria: 1. Other causes of thrombocytopenia, in particular exclusion of underlying diseases or comorbidities such as aplastic anemia, acute leukemia, radiation sickness, immune thrombocytopenia (ITP), hypersplenism, or bone marrow infiltration by tumor cells; 2. Use of non-anti-tumor medications known to cause thrombocytopenia (including but not limited to sulfonamides and other drugs); 3. Pseudothrombocytopenia induced by ethylenediaminetetraacetic acid (EDTA) anticoagulant; 4. Uncontrolled malignant tumor, hypertension, or diabetes mellitus; 5. Active infection, including but not limited to known HIV positivity, active hepatitis B or C, or syphilis; 6. Poor compliance; 7. Known allergy or hypersensitivity to any component of the study intervention (umbilical cord blood or related products); 8. Participation in another clinical trial within 1 month prior to enrollment or current participation in another clinical trial; 9. Any other condition that, in the investigator's judgment, makes the patient unsuitable for participation in this clinical study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Department of Hematology, Zhejiang Cancer Hospital
RECRUITINGHangzhou, Zhejiang, 310000, China
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Other studies related to the condition(s) this trial covers.
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- Cord blood cells aim to speed platelet recovery in transplant patients
- Platelet transfusions may influence blood vessel health in critically ill patients
- New drug strategy may reduce blood transfusions after organ transplants