TBI (TRAUMATIC BRAIN INJURY)

This study tests whether giving a concentrated saltwater solution early after a traumatic brain injury can help patients survive and regain independence. About 760 adults with severe head injuries will receive either the saltwater infusion or standard care. The goal is to see if …

This study looks at whether a quick blood test can help emergency room doctors better decide which patients with mild traumatic brain injury (TBI) actually need a CT scan. Researchers will track how often patients with a normal blood test result still get a CT scan, and identify …

This study tests a program designed to help refugees and asylum seekers who have had a traumatic brain injury (TBI) and now struggle with thinking and memory. Researchers want to see if the program is practical and acceptable to participants. 50 people will be randomly assigned t…

This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve memory, thinking, and mental health in veterans with traumatic brain injury, PTSD, or concussion. Researchers will measure changes in PTSD symptoms, depression, anxiety…

This study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for ICU patients with traumatic brain injury. Researchers will check if it reduces inflammation in the blood and affects vital signs like blood pressure and brain pressure. T…

This study is testing whether a special electrode placed deep in the brain can detect harmful electrical waves called cortical spreading depolarizations (CSDs) after a traumatic brain injury (TBI). These waves are thought to cause further damage, but they are hard to detect with …

This study looks at whether cognitive remediation (brain exercises with coaching) can improve thinking skills and reduce problem behaviors in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use will take part. Th…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and remove medications too quickly. It focuses on adults in the intensive care unit with life-threatening brain problems like stroke, severe injury, or infection. Researchers w…

This study looks at people who had a traumatic brain injury and were treated with hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) 1 to 4 years ago. Researchers want to see if the improvements in thinking and memory from that treatment are still there. A…

This study looks at how a concussion before age 6 might change a child's brain structure and behavior. Researchers will use MRI scans to compare 30 children with a concussion to 30 children with a broken arm or leg. The goal is to better understand the short- and long-term effect…

This study watches children from birth to 18 years old who need anesthesia for an MRI. It measures how different anesthetics change blood flow and oxygen use in the brain. The goal is to learn, not to treat. Up to 1,000 children will join.

This early study is testing whether a non-invasive brain stimulation technique called TACS can help improve thinking and decision-making after a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults to see if the approach is feasible and well-tolerated.…