TBI (traumatic brain injury)

This early study tests a new, noninvasive laser treatment called Nano-Pulsed Laser Therapy (NPLT) for people with moderate to severe traumatic brain injury (TBI). The goal is to see if the treatment is safe and can be given soon after injury. Researchers will also check if the la…

This trial compares two common treatments—hypertonic saline and mannitol—to see which is better at reducing dangerously high pressure inside the skull after a severe traumatic brain injury. The study includes 100 adults with severe head injuries and uses a simple ultrasound measu…

This trial tests whether pairing vagus nerve stimulation (VNS) with structured upper limb rehabilitation can improve arm and hand function in people with moderate to severe traumatic brain injury (TBI). Participants will have a small VNS device implanted under the skin that deliv…

This study tests whether deep brain stimulation (DBS) — a device that sends gentle electrical pulses to a key brain region — is safe and usable for people with chronic moderate to severe traumatic brain injury. Forty adults who are at least two years past their injury will receiv…

This study tests whether an interactive virtual reality (VR) system, where patients move to play games, can improve arm and leg function better than just watching VR. Sixty adults recovering from a stroke or traumatic brain injury will use the VR system three times a week for eig…

Researchers at Al-Nahrain University are developing a new clinical score called fREMS to predict the risk of dying in the hospital for patients with traumatic brain injury. The score combines the FOUR score, which measures consciousness, with physiological and clinical factors fr…

This study tests an adapted version of a therapy called STAIR-NT, designed to help first responders who have both PTSD and a history of traumatic brain injury. The therapy combines skills training and narrative therapy to address emotional regulation and interpersonal issues. Res…

This study tests whether a home-based device that uses rhythmic music to guide walking can help adults with moderate to severe traumatic brain injury improve their mobility, balance, and overall recovery. Participants use the MR-001 device at home for 30 minutes, three times a we…

This study tests whether adding the sleep medication suvorexant to a shortened form of exposure therapy helps veterans with PTSD and insomnia. Participants take suvorexant or a placebo nightly for 8 weeks while attending weekly therapy sessions. Researchers measure changes in PTS…

This study will test a new device that combines a brain-sensing headband with Apple's Vision Pro goggles to help people with ALS, brain injury, or spinal cord injury communicate. Up to 10 participants will use the system for 3-4 months to see how well they can type and control a …

This study looks at how inflammation in the nervous system affects pain and recovery after elbow fractures or dislocations. Researchers will take blood samples from 60 adults before and after surgery to measure specific inflammatory markers. The goal is to better understand why s…