SUBJECTIVE COGNITIVE DECLINE (SCD)

This study tests a smart system that reads facial expressions during computer-based brain training to keep older adults (ages 60-89) at risk for Alzheimer's engaged and focused. The goal is to improve long-term adherence to at-home cognitive exercises. Researchers will compare tr…

This study tests a drug called NPC-1 (made of two compounds) in 40 adults aged 55+ who have Alzheimer's disease, mild cognitive impairment, or subjective memory concerns. The goal is to see if NPC-1 is safe and can improve blood markers related to Alzheimer's brain changes. Parti…

This study looks at whether adding technology (a website and virtual coaching) to basic education and goal-setting can help older adults who live alone, have mild memory concerns, and are not very active to increase their physical activity. The goal is to see if more activity, al…

This study tests whether playing soft sounds during deep sleep can improve memory and slow cognitive decline in older adults. Sixty people aged 60-85 with mild memory problems will use a home device for 4 weeks. Researchers will measure memory, brain activity, and blood markers t…

This study tests whether a rapid form of brain stimulation, called accelerated deep Transcranial Magnetic Stimulation (dTMS), combined with memory exercises can safely improve thinking and memory in older adults who have mild memory issues. About 30 participants aged 55-85 will r…

This study tests whether a 24-week online positive psychology program can improve memory, thinking, and well-being in older adults with very early signs of dementia. About 128 people with subjective cognitive decline or mild cognitive impairment will join. Half take the program (…

This study tests a program called the Green Activity Program, designed for people with mild memory issues or early Alzheimer's. The program encourages enjoyable outdoor activities like walking, gardening, or yoga with a friend or pet. Researchers want to see if the program is eas…

This study tests whether a digital program called RICORDO can help people aged 50+ with mild memory problems better manage their own health and daily life. Participants will use RICORDO or a standard education program at home for five weeks. Researchers will compare changes in he…

This observational study will follow 50,000 people with Alzheimer's or related dementias for many years, collecting medical information from routine doctor visits. Researchers hope to better understand how the disease progresses and how well treatments work in everyday practice. …

This study aims to find better, cheaper ways to detect Alzheimer's disease early in people who have memory complaints but still function normally. Researchers will collect blood, brain wave, and speech data, along with genetic information, and use machine learning to build a pred…

This study follows 1,000 adults who have early memory concerns but no dementia. Researchers will use blood tests and yearly check-ups over 5 years to learn who may be at risk for Alzheimer's disease. The goal is to better understand early signs and improve future prevention strat…

This study follows 1,573 Canadians aged 50–90 with various types of dementia or normal memory to track how brain health changes over time. Participants complete memory tests, brain scans, and provide blood samples. The goal is to better understand different forms of dementia, not…