STRESS DISORDERS, POST-TRAUMATIC

This study tests whether adding a brief writing exercise called AWARE to standard PTSD therapies (CPT or PE) can improve communication between patients and therapists and lead to better outcomes. About 54 adults with PTSD will participate, first in a small pilot phase and then in…

This study tests a short, 3-session program called MERA (Manage Emotions to Reduce Aggression) for veterans with PTSD who struggle with impulsive aggression. The goal is to help them better control their emotions and reduce aggressive outbursts, preparing them for more in-depth P…

This study tests an online self-help program for current or former public safety personnel (like police, firefighters, paramedics) who experience depression, anxiety, or post-traumatic stress. About 164 participants will use a web-based cognitive behaviour therapy course from hom…

This study tests a noninvasive technique called Energy Resonance by Skin Stimulation (ERCS) to reduce stress in patients recovering from an intensive care unit (ICU) stay. The technique uses gentle touch on specific skin points, based on traditional Chinese medicine principles. R…

This study tests whether adding a group-based stabilization and skill-training program to regular individual therapy helps people with long-lasting post-traumatic stress recover better. About 160 adults already receiving outpatient mental health care will take part. Half will get…

This study tests a new EEG neurofeedback system called Prism to see if it can reduce PTSD symptoms in 250 US veterans and civilians. Participants will do 15 training sessions over 8 weeks, plus two booster sessions. The study compares real Prism training to a sham version to meas…

This study explores whether MDMA-assisted therapy can help new mothers (6 to 12 months after childbirth) who struggle with both post-traumatic stress disorder (PTSD) and opioid use disorder. Fifteen participants will receive the therapy alongside their usual medication for opioid…

This study tests whether adding a memory-enhancing technique to standard PTSD therapy helps older veterans learn and remember therapy content better. Thirty veterans over age 59 with PTSD will receive cognitive processing therapy with or without the memory intervention. The goal …

This study tests whether a numbing injection in the neck (stellate ganglion block) can make a proven talk therapy for PTSD work better. About 140 military members or retirees with PTSD will get either the real injection or a fake one, plus ten 90-minute therapy sessions. Research…

This study tests whether extra support from a doula (a trained birth coach) can help mothers of premature babies in the NICU feel less stressed, depressed, or anxious. Twenty mothers will receive doula support and help coordinating care, both in the hospital and after going home.…

This study looks at whether two types of talk therapy can help people who feel dirty inside after a sexual assault, even though they are physically clean. The study will enroll 12 adults with PTSD and these feelings. They will receive either Cognitive Processing Therapy or a Self…

This study tests a new approach to treat PTSD by weakening traumatic memories. Participants take propranolol (a blood pressure drug) before briefly recalling their trauma, sometimes in an unexpected way (like singing the story). The goal is to see if this 'mismatch' method reduce…

This study tests a 3-session program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use. The program teaches veterans about whole health and how to communicate their needs to doctors and loved ones. Researchers want to see if it improves soc…

This study tests whether people can reduce the emotional pain of intrusive memories by themselves using alternating bilateral stimulation (like eye movements or tapping). 150 adults with PTSD or high stress will try this technique at home. The goal is to see if it makes upsetting…

This study tests whether a small device that gently stimulates a nerve in the neck can reduce PTSD symptoms in veterans. Eighty veterans will use the device or a fake version at home twice daily for three months. Researchers will measure changes in brain activity, heart function,…

This study looks at why people with PTSD have a higher chance of heart disease and high blood pressure. Researchers want to understand what causes high adrenaline levels during stress in PTSD patients. They will also test if a medicine called losartan can lower these adrenaline l…

This study looks at how to train therapists better so they can provide more effective PTSD treatment to veterans. Researchers will test different training methods with 240 mental health clinicians to see which ones help therapists stick to the proven therapy plan. The goal is to …