STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Clinical trials for STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8 explained in plain language.
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Radiation boost may supercharge immunotherapy for advanced liver cancer
Disease control Recruiting nowThis study is for people with advanced liver cancer that has spread to nearby blood vessels. It tests whether adding a precise, high-dose form of radiation (SBRT) to standard immunotherapy helps them live longer than immunotherapy alone. About 226 participants will be randomly as…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated May 01, 2026 14:32 UTC
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New combo therapy aims to boost survival in advanced liver cancer
Disease control Recruiting nowThis study tests whether adding the immunotherapy drug atezolizumab to standard targeted drugs (cabozantinib or lenvatinib) works better than the targeted drugs alone for people with advanced liver cancer that cannot be surgically removed. About 122 adults who have already receiv…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE2 • Sponsor: Academic and Community Cancer Research United • Aim: Disease control
Last updated May 01, 2026 14:31 UTC
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New drug combo targets Hard-to-Treat liver cancer in early trial
Disease control Recruiting nowThis study tests two drugs, sapanisertib and cabozantinib, together in people with advanced liver cancer that has a specific change in the β-catenin gene. The goal is to find the best dose and see if the combination works better than cabozantinib alone. About 92 adults with liver…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 01, 2026 14:19 UTC
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Electric field device joins drug combo to fight advanced cancers
Disease control Recruiting nowThis early-phase study tests a wearable device that creates electric fields (tumor treating fields) combined with either cabozantinib or a chemo-immunotherapy pair (nab-paclitaxel and atezolizumab) in people with advanced solid tumors in the abdomen or chest. The goal is to see i…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Apr 30, 2026 15:52 UTC
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New drug AU409 enters first human tests for tough liver cancers
Disease control Recruiting nowThis early-phase trial tests a new drug called AU409 in people with advanced liver cancer or other cancers that have spread to the liver. The main goals are to find the safest dose and see what side effects occur. About 36 adults whose cancer has not responded to standard treatme…
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: PHASE1 • Sponsor: University of Southern California • Aim: Disease control
Last updated Apr 29, 2026 15:05 UTC
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Scientists peek inside tumors during surgery to see how they behave
Knowledge-focused Recruiting nowThis study uses a special microscope to look at blood vessels inside solid tumors while patients are having surgery. The goal is to understand how these vessels work, which could help doctors decide if a patient's tumor is likely to respond to certain treatments. About 85 adults …
Matched conditions: STAGE IV HEPATOCELLULAR CARCINOMA AJCC V8
Phase: NA • Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Apr 30, 2026 15:52 UTC