STAGE III RECTAL CANCER AJCC V8
Clinical trials for STAGE III RECTAL CANCER AJCC V8 explained in plain language.
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New combo therapy targets hard-to-treat colorectal cancer
Disease control OngoingThis study tests a new drug, SX-682, alone and with the immunotherapy nivolumab, in people with a specific type of advanced colorectal cancer that has spread or cannot be removed. The cancer must have a RAS mutation and be microsatellite stable (MSS), which often makes it harder …
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 15, 2026 19:06 UTC
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Immunotherapy plus radiation may eliminate rectal cancer before surgery
Disease control OngoingThis study tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) along with a short course of radiation can completely eliminate advanced rectal cancer before surgery. About 31 adults with a specific genetic type (MSI-H/dMMR) of stage II or III rectal cancer wil…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 15, 2026 19:04 UTC
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New chemo cocktail may help rectal cancer patients skip surgery
Disease control OngoingThis study tests whether a three-drug chemotherapy combination (FOLFIRINOX) works better than the usual two-drug combinations (FOLFOX or CAPOX) after chemoradiation for patients with stage II-III rectal cancer. The goal is to achieve a clinical complete response, meaning no cance…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: PHASE2 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Jun 15, 2026 18:56 UTC
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New drug combo aims to shrink rectal tumors before surgery
Disease control OngoingThis early-stage study tests the safety of combining the chemotherapy drug TAS-102 with radiation therapy for people with stage II or III rectal cancer that hasn't been treated yet. The goal is to find the safest dose of TAS-102 to use with radiation before surgery to remove the …
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: PHASE1 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Jun 15, 2026 18:55 UTC
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Immunotherapy combo shows promise for Hard-to-Treat colorectal cancer
Disease control OngoingThis study looks at whether adding an immunotherapy drug (nivolumab) to the usual two-drug treatment can better shrink tumors in people with a specific type of advanced colorectal cancer (BRAF-mutated, microsatellite stable). About 86 adults whose cancer has spread or can't be re…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 12, 2026 12:03 UTC
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New scan could sharpen view of rectal cancer during treatment
Diagnosis OngoingThis early-phase trial tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to highlight rectal cancer cells. The goal is to see if this scan can show tumor extent and response more accurately than standard imaging before and after chemotherapy and radiation. About …
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Phase: EARLY_PHASE1 • Sponsor: City of Hope Medical Center • Aim: Diagnosis
Last updated Jun 15, 2026 18:56 UTC
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Blood tests could reveal secrets of rectal cancer
Knowledge-focused OngoingThis study looks at tiny pieces of cancer cells or DNA floating in the blood of people with rectal cancer. Researchers want to see if these markers can help predict how the tumor responds to standard treatment. About 341 participants, including healthy volunteers, will provide bl…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 22, 2026 12:05 UTC
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Cancer treatment costs under the microscope: new study tracks financial toll
Knowledge-focused OngoingThis study follows 565 people with stage I-III colon or rectal cancer to understand how treatment affects their finances and quality of life. Participants complete surveys about costs and financial well-being over 12 months. The goal is to help doctors better support patients fac…
Matched conditions: STAGE III RECTAL CANCER AJCC V8
Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Knowledge-focused
Last updated Jun 16, 2026 12:51 UTC