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New drug combo aims to shrink rectal tumors before surgery

NCT ID NCT04104139

First seen Oct 31, 2025 · Last updated Jun 14, 2026 · Updated 44 times

Summary

This early-stage study tests the safety of combining the chemotherapy drug TAS-102 with radiation therapy for people with stage II or III rectal cancer that hasn't been treated yet. The goal is to find the safest dose of TAS-102 to use with radiation before surgery to remove the tumor. The study enrolled 19 adults and is currently active but not recruiting new participants.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • OHSU Knight Cancer Institute

    Portland, Oregon, 97239, United States

Conditions

The condition(s) this trial relates to.

rectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.