SOLID TUMORS

This early-phase study tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The goal was to find a safe dose and see how the drug affects the body. TdCyd is taken by mouth in 3-week cycles, and researchers moni…

This study tested an experimental drug called IDX-1197 in 108 adults with solid tumors that have a specific gene change (HRR mutation). The goal was to find a safe dose and see if the drug could shrink tumors. Participants had cancers that stopped responding to standard treatment…

This early-stage study tested an experimental drug, MK-1454, given as a shot into tumors, either alone or with the immunotherapy pembrolizumab. The goal was to find the safest dose and see if the combination could shrink tumors in people with advanced solid tumors or lymphomas. 1…

This early-phase study tested a combination of two drugs, dasatinib and bevacizumab, in 50 adults with advanced solid tumors that no longer responded to standard treatments. The goal was to find the safest doses and see how the drugs affected the cancer and the body. Participants…

This early-phase study tested a new drug called FF-10502-01 in 106 adults with advanced solid tumors or lymphomas that had stopped responding to standard treatments. The goal was to find the safest dose and see if the drug could shrink tumors or slow disease progression. The stud…

This study tested a drug called revumenib in 42 adults with colorectal cancer or other solid tumors that had spread or come back after at least one prior treatment. The main goals were to check safety, find the right dose, and see if the drug could shrink tumors or slow their gro…

This early-phase study tested a new drug called RS-0139 in 16 people with advanced solid tumors that had come back or spread. The goal was to find the safest dose and see how the drug works in the body. The drug is designed to target tumors directly, and researchers monitored sid…

This early-phase study tested a new combination of immune cells in 9 people with stage IV solid tumors that had stopped responding to standard treatments. The main goal was to check safety and side effects, while also looking for signs that the therapy might shrink or control the…

This early-phase trial tested whether adding nilotinib (a pill) to paclitaxel (an IV chemo drug) is safe for people with advanced solid tumors that have stopped responding to standard treatments. 47 adults and children aged 12 and older took part. The goal was to find the safest …

This study tested a drug called bemarituzumab in 260 adults with solid tumors that have too much of a protein called FGFR2b. The main goals were to see if the drug is safe and if it can shrink tumors. Participants had cancers that stopped responding to standard treatments.

This early-phase study tested a new drug called eciskafusp alfa (RO7284755) in 189 adults with advanced solid tumors that had stopped responding to standard treatments. The drug works by helping the immune system attack cancer cells. Some participants received the drug alone, and…

This early-phase study tested whether immune cells called natural killer (NK) cells could be safely given to children and young adults with solid tumors that did not respond to standard treatments. Sixteen participants received their own activated NK cells, with or without a prot…

This early-phase study tested a new type of cell therapy (CAR-T cells) designed to attack tumors that have a protein called ALPP. Five adults with advanced solid tumors that had no standard treatment options received the therapy. The main goals were to check safety and see if the…

This early-phase study tested a new drug called DF6002, given alone or with the immunotherapy nivolumab, in 170 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety, find the right dose, and see if the drug shri…

This early-stage study tested a new drug called CFT1946 in 89 adults with advanced solid tumors that have a specific BRAF V600 gene change. The goal was to find safe doses and see if the drug, given alone or with other medicines, can shrink tumors. The study focused on safety and…

This study looked at whether taking statins (common cholesterol-lowering drugs) can help prevent hearing loss and other side effects caused by platinum-based chemotherapy in people with solid tumors. 56 adults who were about to start chemotherapy took part. Researchers measured h…

This early-phase study looked at how the cancer drug belinostat is processed in the body depending on a person's UGT1A1 gene type. It included 17 adults with advanced solid tumors or blood cancers that had stopped responding to standard treatments. Researchers measured drug level…

This study in France asked 49 adults with solid tumors how they felt about switching from hospital to home for their immunotherapy treatments. Researchers measured changes in patient satisfaction using a standard questionnaire. The goal was to understand if receiving care at home…

This study looked at 225 adults with solid tumors who experienced bone pain from a drug called G-CSF, given during chemotherapy. Researchers measured pain levels and tracked which pain relief methods worked best, including medications and non-drug approaches. The goal was to find…

This study looked at how a new cancer drug (BI 907828) interacts with two common medicines: rifampicin (an antibiotic) and itraconazole (an antifungal). 33 adults with advanced solid tumors took BI 907828 alone and then with each other drug. Researchers measured drug levels in th…

This study tested tumor tissue from 470 people with solid tumors to look for specific biomarkers. The goal was to see if those biomarkers could help decide who might be eligible for other Roche clinical trials. No treatment was given in this study—it was only about gathering info…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study tested whether a computer could learn to recognize cancer pain by analyzing people's facial expressions and voices. 83 people with cancer recorded short videos at the clinic and at home over three months. The goal was to see if this technology could be a useful tool fo…