SOLID TUMOR MALIGNANCIES

This study is testing whether giving standard cancer immunotherapies less frequently but at higher doses causes more severe side effects than giving them more frequently at lower doses. Researchers are enrolling 192 adults with various solid tumors who are eligible to receive pem…

This is a first-in-human study to test the safety and early effectiveness of an experimental oral drug called KQB548. It is for adults with advanced pancreatic, colorectal, or lung cancers that have a specific genetic change called KRAS G12D and have stopped responding to standar…

This Florida-based study is testing whether an AI platform can quickly find personalized treatment options for cancer patients whose disease has returned or stopped responding to standard treatments. The program will enroll 210 patients, with special focus on underserved communit…

This is the first study in people to test a new oral drug called AO-252 for advanced solid tumors, including cancers that have spread to the brain. The main goals are to find a safe dose and see how well the body handles the drug. It will involve about 86 adults whose cancer has …

This is the first study in humans of an experimental tablet called SWA1211 for people with advanced solid tumors that have not responded to standard treatments. The main goals are to find a safe dose, understand how the body processes the drug, and look for early signs that it mi…

This is the first study in people testing KQB168, a new cancer drug, for adults with advanced solid tumors that have stopped responding to standard treatments. Researchers want to find the safest dose of KQB168 when taken alone or combined with another cancer drug (pembrolizumab)…

This early-stage study is testing a new oral drug called CP-383 in people with advanced solid tumors that have spread or returned. The main goals are to find a safe dose and see if the drug can slow or stop cancer growth. It is for patients who have run out of standard treatment …

This is the first human study of a new experimental drug called VIR-5525 for people with advanced solid tumors that have spread or cannot be removed by surgery. Researchers will test VIR-5525 alone and combined with an existing immunotherapy drug (pembrolizumab) in 450 participan…

This is the first-ever study in people of an experimental cancer drug called TJ101. The main goal is to find a safe dose and see how the body handles it. The study will also look for early signs that the drug can shrink tumors in adults with advanced cancers who have run out of s…

This is an early safety study testing an experimental drug called SH009 injection in adults with advanced solid tumors who have run out of standard treatment options. The study aims to find a safe dose, see how the body processes the drug, and check for early signs that it might …

This is an early-stage study testing the safety of a new treatment called GO306, a genetically modified virus designed to infect and kill cancer cells. It is being given as an injection directly into tumors or into body cavities for adults with advanced solid tumors that have not…

This study is testing a new, personalized approach to treat advanced cancers that are no longer responding to standard therapies. Doctors will take a small sample of a patient's tumor and grow it in a lab to create a 'mini-tumor' model. They will then test many different cancer d…

This is an early-stage study to check the safety and find the right dose of an experimental injection called SXRN. It is for adults with advanced cancer who are experiencing severe, unintentional weight loss and loss of appetite, known as cachexia. The study will first test SXRN …

This study aims to understand how the cancer drug olutasidenib affects how the body processes other medications. Researchers will measure blood levels of several test drugs in 16 adult patients with specific genetic mutations in their cancers. The goal is to learn about potential…

This study is exploring whether testing spinal fluid can better detect cancer that has spread to the brain or its lining compared to standard blood tests. Researchers will collect spinal fluid and blood from 60 patients with solid tumors, including those with and without brain me…