SMALL CELL LUNG CARCINOMA

This study is testing several new investigational drugs, given alone or in combination with an existing immunotherapy drug (pembrolizumab), for people with an aggressive form of lung cancer called extensive-stage small cell lung cancer. The cancer in these participants has contin…

This is the first study in people to test a new oral medication called NKT3964. The main goals are to find a safe dose and see if the drug shows early signs of shrinking tumors in adults with advanced cancers that have spread and no longer respond to standard treatments. The stud…

This study is testing whether a precise, high-dose radiation treatment called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. It will measure how many participants are still alive 6 months after receiving the treatment. Th…

This study is testing whether people with a specific type of lung cancer can be safely monitored at home after receiving a new drug called tarlatamab, instead of staying in the hospital. It aims to see if a 'Hospital-at-Home' program is a more efficient way to deliver care. The r…

This is an early-stage study to test the safety and find the right dose of a new radioactive drug called [225Ac]Ac-ETN029 for adults with advanced cancers that have a protein called DLL3. The trial will also test an imaging version of the drug to see where it goes in the body. Re…

This is the first human trial of a new experimental cancer drug called LY4175408. It is designed to target and deliver a toxic payload specifically to cancer cells that have a certain marker (PTK7). The study will test the drug's safety, side effects, and early signs of effective…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This early study is testing the safety of a new cell therapy for adults with advanced lung cancer that has stopped responding to standard treatments. Doctors will collect a patient's own immune cells, modify them in a lab to better target cancer, and then infuse them back into th…

This study is testing the safety and effectiveness of the immunotherapy drug durvalumab for people in Spain with a specific, aggressive type of lung cancer called limited-stage small cell lung cancer. The drug is given after patients have completed standard chemotherapy and radia…

This study is testing whether a drug called onvansertib can help people with small cell lung cancer that has returned after chemotherapy. Researchers will give the drug to 37 patients who have already tried one or two chemotherapy treatments. They want to see if the drug shrinks …

This study is testing whether adding a new drug called cirtuvivint to standard chemotherapy can better control small cell lung cancer that has returned after initial treatment. It will enroll about 42 adults whose cancer has progressed after prior platinum-based chemotherapy. The…

This study is testing a new drug called BI 764532 for adults with advanced small cell lung cancer or other neuroendocrine cancers that have returned or stopped responding to standard treatments. The main goals are to find a safe and effective dose and to see if the drug can shrin…

This early-stage trial is testing the safety and dosing of an experimental drug called PF-08046050 in adults with advanced solid tumors that have returned or stopped responding to standard treatments. The drug is designed to attach to cancer cells and deliver a toxic payload dire…

This study is testing a new type of imaging scan to see if it can safely and effectively detect small cell lung cancer and similar tumors. Participants receive a special tracer injection and then undergo a PET/CT scan. The main goals are to check the safety of the tracer and see …

This study aims to understand why some people develop lung cancer at age 45 or younger, which is unusual. Researchers will collect blood, saliva, and tumor samples from 500 participants to look for genetic patterns and risk factors. The goal is to gather knowledge that could lead…

This study aims to collect long-term health information and blood/tissue samples from 730 lung cancer patients treated at Nantes University Hospital. By tracking patients from diagnosis through their entire treatment journey, researchers hope to understand how treatments work in …