SICKLE CELL ANEMIA
Clinical trials for SICKLE CELL ANEMIA explained in plain language.
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CRISPR gene therapy aims to free patients from lifelong transfusions
Disease control Recruiting nowThis study tests a single dose of a CRISPR-based gene therapy (CTX001) in 26 adults with transfusion-dependent beta-thalassemia or severe sickle cell disease. The treatment uses the patient's own blood stem cells, which are edited to produce more fetal hemoglobin, potentially red…
Matched conditions: SICKLE CELL ANEMIA
Phase: PHASE3 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Disease control
Last updated May 26, 2026 04:58 UTC
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Can a common bone drug ease pain in sickle cell disease?
Disease control Recruiting nowThis study is testing whether alendronate, a drug used for osteoporosis, can help treat bone damage (osteonecrosis) in adults with sickle cell disease. About 30 participants will take the drug for 6 months to see if it reduces pain and improves quality of life. The study also che…
Matched conditions: SICKLE CELL ANEMIA
Phase: PHASE2 • Sponsor: University of California, Davis • Aim: Disease control
Last updated May 19, 2026 11:46 UTC
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Blood donors needed to speed up sickle cell drug discovery
Knowledge-focused Recruiting nowThis study collects blood samples from 250 adults with sickle cell disease, sickle cell trait, or healthy red blood cells. Researchers will use the samples to test thousands of compounds, including existing FDA-approved drugs, to find new treatments for sickle cell disease. Parti…
Matched conditions: SICKLE CELL ANEMIA
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated May 22, 2026 13:54 UTC
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New study tracks Long-Term effects of sickle cell drug on fertility
Knowledge-focused Recruiting nowThis study follows 250 people with sickle cell anemia, ages 8 and up, over many years to see how the medicine hydroxyurea affects their growth, puberty, and ability to have children. Researchers will also compare pregnancy outcomes between those who take the drug and those who do…
Matched conditions: SICKLE CELL ANEMIA
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated May 20, 2026 11:55 UTC
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Sickle cell Kids' measles protection under the microscope
Knowledge-focused Recruiting nowThis study looks at whether infants and young children with sickle cell disease (SCD) get enough protection from the standard measles vaccine. Researchers will measure antibody levels in 130 children with SCD after they receive their routine measles shots. The goal is to understa…
Matched conditions: SICKLE CELL ANEMIA
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Apr 28, 2026 13:02 UTC