SEPSIS, SEVERE

This study looks at whether giving gamma globulin (a blood product with antibodies) can help children in intensive care who have severe infections and a dangerous overreaction called an inflammatory storm. The goal is to see if it lowers the death rate and shortens hospital stays…

This study compares two strategies for giving steroids to adults with severe infections and low blood pressure. One group gets steroids very early, the other gets them only if standard medicines fail. The goal is to see which timing reduces deaths within 28 days. About 230 partic…

This study tests whether a program that includes guidelines, feedback, and education can help doctors use less vancomycin (a strong antibiotic) in children with suspected sepsis in intensive care units. The goal is to reduce side effects like kidney damage while still treating in…

This study looks at whether a device that measures brain activity (called BIS) can help doctors quickly tell how severe a patient's sepsis is. Sepsis is a life-threatening response to infection that can affect the brain. The researchers will compare BIS readings with a standard b…

This observational study looks at whether certain genetic elements, called transposable elements, can prematurely age the immune system of people with sepsis in the ICU. Researchers will collect blood samples from 116 adult patients to see if these elements are linked to higher d…

This study observes about 1,950 emergency patients with suspected sepsis to see how well certain blood markers (like calprotectin) and rapid DNA tests can detect infections. The goal is to improve diagnosis and tailor treatment to each patient. Participants are adults admitted to…

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve early …