SCLC

This program offers the experimental drug I-DXd to adults with extensive-stage small cell lung cancer who have already tried at least two prior treatments, including platinum-based chemotherapy. It is for people who have no suitable treatment options and cannot join a clinical tr…

This study tests a new drug called ZL-1310, given alone or with other medicines, for people with small cell lung cancer. The goal is to see if it is safe and helps control the cancer. About 339 adults with advanced or spreading small cell lung cancer will take part. The study is …

This early-stage study tests a new drug called SLV-154 in about 70 adults with advanced solid tumors that have spread. The main goal is to find the safest dose and check for side effects. Participants have cancers like head and neck, lung, breast, or ovarian cancer that haven't r…

This study observes how well the drug Zepzelca works and how safe it is for people with metastatic small cell lung cancer who have already tried platinum-based chemotherapy. About 300 participants will be followed in real-world clinics, not a lab. The goal is to see how many pati…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment will take the drug al…

This early-phase study tests a new drug called HLX3901 in people with advanced small cell lung cancer or neuroendocrine carcinoma. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. About 138 adults aged 18 to 75 will take part.

This study tests whether adding golidocitinib to standard PD-1 inhibitor maintenance therapy can help keep extensive-stage small cell lung cancer from progressing. About 20 adults with untreated advanced disease will receive the combination after initial chemo. The goal is to see…

This study tests a combination of two drugs, monalizumab and durvalumab, along with standard chemotherapy, for people with small cell lung cancer. The goal is to see if this mix helps keep the cancer from growing longer. About 84 adults with either extensive-stage or limited-stag…

This study tests a new drug called JAB-8263 in adults with advanced solid tumors or blood cancers that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 152 people will take part in this early-phase tr…

This early-phase trial tests a new drug, TUB-030, in adults with advanced solid tumors like head and neck, lung, breast, or colorectal cancer. The main goals are to find a safe dose and check for side effects. Researchers will also compare different doses in people with head and …

This study tests a new radioactive probe called PFD3 that targets a protein (DLL3) found on small cell lung cancer cells. Using PET/CT scans, doctors hope to see tumors more clearly and assess the cancer's spread. About 30 adults with confirmed small cell lung cancer will receive…