SCLC

This study is testing a combination of two drugs, MEDI4736 (which helps the immune system fight cancer) and olaparib (which targets cancer cells with DNA repair problems), in people with advanced solid tumors like ovarian, breast, lung, and stomach cancers. The goal is to see if …

This study tests whether combining two drugs, lurbinectedin and berzosertib, can shrink tumors in people with small cell lung cancer or high-grade neuroendocrine cancers. These cancers often stop responding to standard chemotherapy. The trial involves 37 adults and aims to find t…

This study tests a combination of two drugs, sacituzumab govitecan and berzosertib, in adults with small cell lung cancer or certain resistant cancers. The goal is to find a safe dose and see if the combo can shrink tumors. Participants receive the drugs by vein twice per cycle a…

This study tests an experimental oral drug, MRT-2359, in people with certain advanced cancers, including lung cancer and lymphoma, that are driven by MYC genes. The trial has two phases: first, finding a safe dose, and second, checking if the drug shrinks tumors. About 174 adults…

This study looks at adults with certain cancers (like lung, breast, kidney, or melanoma) that have spread to the brain. All participants are also receiving immunotherapy. The goal is to see if giving a lower dose of radiation over a few days causes fewer side effects than the sta…

This study looks at how small differences in genes (called SNPs) might influence how well the drug topotecan works and what side effects it causes in people with small cell lung cancer. Researchers will test 600 patients who are already taking topotecan, using precise DNA sequenc…