SARCOIDOSIS

This study compares two treatments for cardiac sarcoidosis, a condition where inflammation damages the heart. About 194 adults with active heart sarcoidosis will get either a low-dose prednisone/methotrexate combo or standard-dose prednisone alone. The goal is to see if the combo…

This study explores a new blood test that may detect active heart inflammation in people with sarcoidosis, a disease that can cause serious heart problems. Researchers will measure DNA fragments released from damaged heart cells in 120 participants, including healthy volunteers a…

This study tests whether an 8-week virtual Mindfulness-Based Stress Reduction (MBSR) program can reduce fatigue in people with sarcoidosis. It also looks at effects on anxiety and depression. About 100 adults with sarcoidosis and fatigue will either join the MBSR program or a mon…

This study looks at the best way to slowly reduce steroid medication in people with stable sarcoidosis, an inflammatory disease. About 100 adults who have been on a low dose of prednisolone for at least 6 months will be randomly assigned to a standard or a faster tapering schedul…

This study is looking for new genes and blood markers that can help predict who will get arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can cause sudden cardiac arrest. Researchers will enroll 1000 people, including patients with AVC or unexplained cardiac ar…

This study is building a large collection of health information and blood samples from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers will use this data to find links between patient outcomes and biological markers. The goal is…

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track patients' health, treatments, and outcomes over time. The goal is to better understand these conditions and improv…

This study looks at how vitamin D levels relate to the severity of sarcoidosis, a disease that causes inflammation in the body. Researchers will give vitamin D supplements or a placebo to 90 people with sarcoidosis who have low vitamin D, and compare their lung function and quali…

This study looks at how certain immune cells (monocytes and macrophages) behave in people with sarcoidosis, an inflammatory disease, compared to those with tuberculosis. Researchers will analyze blood and tissue samples from 100 participants to find patterns that may explain why …

This study is looking at 5,000 people with sarcoidosis, an inflammatory disease that can affect the lungs and other organs. Researchers want to understand why some people get better while others develop long-term problems. They will study genes, immune cells, and gut bacteria, an…

This study is testing a new imaging method called full-field optical coherence tomography (FFOCT) on small lung biopsy samples. The goal is to see if FFOCT can give the same information as the standard lab analysis, but faster. About 20 adults with lung cancer or sarcoidosis who …

This study is creating a registry and biobank for people with interstitial lung diseases (ILD), including sarcoidosis and pulmonary fibrosis. Researchers will collect medical data and biological samples from up to 1,000 participants to support future studies. The goal is to bette…

This study creates a long-term record of experiences from people living with sarcoidosis. Participants answer surveys about symptoms, diagnosis, treatment, and daily life, and can share their electronic health records. The goal is to better understand the disease and support futu…

This study looks at how immune cells behave in lung cancer, COPD, and sarcoidosis. Researchers want to understand why some people don't respond to immunotherapy. The goal is to gather knowledge that could lead to more personalized treatments in the future. About 425 participants,…