Rheumatic heart disease
Clinical trials for Rheumatic heart disease explained in plain language.
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Can community hospitals in zambia master severe disease care?
Disease control Recruiting nowThis trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…
Matched conditions: RHEUMATIC HEART DISEASE
Sponsor: Centre for Infectious Disease Research in Zambia • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Penicillin break: major trial tests if kids with mild RHD can ditch daily antibiotics
Disease control Recruiting nowThis Phase 3 trial will test whether children and teens with mild rheumatic heart disease (RHD) can safely stop taking long-term penicillin. About 922 participants aged 5-20 who have stable or normalized RHD after at least 2 years of antibiotics will be randomly assigned to eithe…
Matched conditions: RHEUMATIC HEART DISEASE
Phase 3 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Uganda program aims to stop heart disease in its tracks
Disease control Recruiting nowThis study looks at a program called ADUNU, which aims to find and treat people with rheumatic heart disease in two districts of Uganda. The program uses portable ultrasound to screen for the disease and a registry to keep patients on preventive medication. Researchers will check…
Matched conditions: RHEUMATIC HEART DISEASE
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Shock waves for stiff heart valves: new balloon tested in First-in-Human trial
Symptom relief Recruiting nowResearchers are testing a new balloon device called SmartWave that uses shock waves to break up calcium in severely narrowed mitral valves. The study enrolls 10 adults with symptomatic mitral stenosis caused by mitral annular calcification or severely calcified rheumatic heart di…
Matched conditions: RHEUMATIC HEART DISEASE
Sponsor: Prince of Wales Hospital, Shatin, Hong Kong • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC