Resistant hypertension

Researchers are studying the long-term safety and effectiveness of the Barostim Neo System in people with uncontrolled high blood pressure who already received the implant. Participants continue their usual blood pressure medications while the device stimulates nerves in the neck…

This trial tests an experimental pill called SAL0120, taken once a day, in adults whose blood pressure stays high even when they already take two or more blood pressure medicines. About 256 people aged 18 to 75 with uncontrolled or resistant hypertension will receive either a low…

This Phase 3 trial tested a once-daily pill called baxdrostat in 218 adults with resistant hypertension—high blood pressure that stays high despite taking three or more medications. Participants received either baxdrostat or a placebo for 12 weeks. The main goal was to see if bax…

This Phase 3 trial tested a daily pill called baxdrostat in about 800 adults whose blood pressure stays high even when taking two or more other medications. Participants received either 1 mg, 2 mg, or a placebo for 12 weeks. The main goal was to see if baxdrostat could safely low…

This Phase 3 trial tested a new drug called lorundrostat in over 1,000 adults whose high blood pressure remained uncontrolled despite taking 2 to 5 other medications. Participants received either lorundrostat or a placebo daily for 12 weeks. The main goal was to see if the drug l…

This study tested a new drug called baxdrostat in 326 adults whose high blood pressure was not controlled even with two or more medications. Participants took either 1 mg, 2 mg of baxdrostat, or a placebo daily for 12 weeks. The main goal was to see if baxdrostat could lower syst…

This study tested a new drug called XXB750 in 189 people with resistant hypertension—high blood pressure that doesn't get better with standard treatments. Participants received either a placebo or one of several doses of XXB750 as a shot under the skin, on top of their usual medi…

This study tests whether allopurinol, a common gout medication, can improve heart function in African American veterans with resistant hypertension. Participants take allopurinol for 8 weeks, and researchers measure changes in heart function, exercise ability, and quality of life…

This study tested whether one-on-one sessions with a trained nurse could help people with resistant hypertension better handle side effects like sexual problems and bladder control issues caused by their blood pressure medications. The goal was to see if this education helps pati…

This completed study looked at 111 people to see if measuring blood flow in the skin can help assess cardiovascular risk in those with resistant hypertension (high blood pressure that doesn't respond to multiple drugs). Researchers used a laser device to check how well tiny blood…

This study looked at over 1,100 adults in the US whose high blood pressure stays high despite taking multiple medications. Researchers checked if these people also have a hormone condition called endogenous hypercortisolism, where the body makes too much cortisol. Participants ga…