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Skin blood flow test may predict heart danger in tough-to-treat high blood pressure

NCT ID NCT05464849

Knowledge-focused Sponsor: National Institute of Cardiology, Laranjeiras, Brazil Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at 111 people to see if measuring blood flow in the skin can help assess cardiovascular risk in those with resistant hypertension (high blood pressure that doesn't respond to multiple drugs). Researchers used a laser device to check how well tiny blood vessels in the skin expand and contract. The goal was to see if these skin measurements could reveal hidden damage to organs and offer a non-invasive way to predict heart problems.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple, non-invasive skin test to better predict heart risks in people with hard-to-treat high blood pressure.
What could go wrong
This is an observational study, not a treatment trial. It only measures blood flow, so it cannot directly improve health. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

111 people

The number who actually took part.

Started

Dec 2021

Finished

Dec 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Resistant hypertension: Blood pressure levels outside the treatment goals in patients using three or more classes of antihypertensive drugs, one of which is preferably a thiazide diuretic.

Ages

18 to 75 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Resistant hypertension Exclusion Criteria: * Pregnancy or lactation for all groups. * For the control group: endocrine and metabolic diseases, including diabetes mellitus, cardiovascular diseases, including hypertension, autoimmune diseases and cancer. * For the resistant arterial hypertension and non-resistant arterial hypertension groups: endocrine diseases, except diabetes mellitus, autoimmune diseases and cancer .

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Conditions

The condition(s) this trial relates to.

essential hypertension hypertensive disorder Microvascular Rarefaction resistant hypertension

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arterial hypertension Endothelial dysfunction Microvascular rarefaction Resistant hypertension

Contacts and locations

Locations

  • Eduardo Tibiriçá

    Rio de Janeiro, 22240006, Brazil

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