RENAL CELL CARCINOMA (KIDNEY CANCER)

This early-stage study tests a new drug called KO-2806 in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find safe doses and see if the drug can shrink tumors when used alone or with other cancer medicines. About 300 participan…

This study tests whether adding precise, high-dose radiation (SBRT) to standard drug therapy (targeted agents and immunotherapy) helps people with kidney cancer that has spread to a few spots (5 or fewer) live longer without the cancer growing. About 252 adults with this type of …

This study tests a new drug, 177Lu-TLX250, which delivers radiation directly to kidney cancer cells that have a specific marker (CAIX). It is for adults with advanced clear cell kidney cancer that has come back or not responded to at least two prior treatments. The trial compares…

This study tests whether weekly digital symptom reports from patients with advanced kidney cancer can help doctors make timely adjustments to their treatment with cabozantinib and nivolumab. About 83 adults starting this combination therapy will use a digital platform to report s…

This study looks at whether people aged 55-70 who smoke or used to smoke can get an extra belly scan during their lung cancer check. The goal is to find kidney cancers, belly aneurysms, and kidney stones early. About 6,200 participants will help test if this addition is practical…

This study gathers information from kidney cancer patients and their partners about their fear of the cancer returning after surgery. Researchers will work with patients to decide the best questions and timing for follow-up. About 105 people will take part to help improve care an…

This observational study is exploring whether levels of a protein called Galectin-3 in the blood are linked to how well patients with kidney, lung, bladder, or liver cancer respond to immunotherapy drugs (PD-1/PDL-1 inhibitors). Researchers will measure Galectin-3 before each tre…

This study looks at how certain immunotherapy drugs (called immune checkpoint inhibitors) affect bone strength in people being treated for cancer. Researchers will measure bone density and blood markers in 25 patients over a year to see if these treatments increase fracture risk.…

This study looks back at data from 4700 kidney cancer patients treated between 2012 and 2024. The goal is to create a tool that predicts how the disease will progress, especially for patients with a tumor clot in a vein. Researchers will then test if using this tool to choose tre…

This study is gathering tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to learn how often certain genetic changes occur and to store participants' own immune cells for possible future use in making …