RECTAL CARCINOMA

This study is testing a more personalized approach to treating advanced rectal cancer. It aims to see if doctors can safely skip radiation therapy for patients who respond very well to initial chemotherapy, potentially reducing side effects. The trial will enroll over 1,000 patie…

This study is testing whether a new, step-by-step dosing guide called the PAGODA algorithm can help prevent unplanned delays in FOLFOX chemotherapy for people with gastrointestinal cancers. About 420 participants will be randomly assigned to have their chemotherapy doses adjusted…

This study is testing whether a new type of CT scanner, called a Photon-Counting Detector CT, can determine how far rectal cancer has grown as accurately as an MRI scan. About 120 adults with rectal cancer will have both scans to compare the results. The goal is to see if this ne…

This study is testing if a structured bowel management program that includes using a special rectal enema is better at relieving symptoms than standard medical care alone. It's for people who have ongoing bowel problems like urgency, incontinence, or constipation after surgery fo…

This study is testing whether a vaginal hormone treatment called DHEA can help improve vaginal health and reduce discomfort for women who have had radiation therapy for certain gynecologic or gastrointestinal cancers. Radiation can cause symptoms like vaginal dryness, pain during…

This early study aims to see how two new radioactive tracers travel through the body and gather in tumors. Researchers will give a single, tiny dose of one tracer to up to 32 patients with various solid tumors and then use PET/CT scans to track where it goes. The main goal is to …