PRIMARY SCLEROSING CHOLANGITIS

This is an early safety study for a new drug called TAK-781. It will first test the drug in healthy volunteers to see if it is safe and how the body processes it. Then, a small group of people with a serious liver disease called primary sclerosing cholangitis (PSC) will receive a…

This study is testing whether an oral medication called BRS201 can help control primary sclerosing cholangitis (PSC), a rare liver disease. For 8 weeks, 28 participants will take either the study drug or a placebo pill in a random order to see if it can normalize a key liver enzy…

This early-stage study is testing the safety of an investigational drug called siplizumab in patients with autoimmune liver disease who are receiving a liver transplant. The drug is given right after surgery to help prevent the body's immune system from attacking the new liver. U…

This study aims to collect bile samples and medical information from people with Primary Sclerosing Cholangitis (PSC) and people without liver disease. Researchers will use these samples to grow tiny 3D liver-like structures called organoids in the lab. By studying these organoid…

This small, early study is testing if a cholesterol-lowering drug called rosuvastatin changes bile acids and gut bacteria in people with primary sclerosing cholangitis (PSC), a rare liver disease with no cure. The goal is to understand the biology of PSC better, which could help …

This study aims to understand the biological causes of Primary Sclerosing Cholangitis (PSC), a rare and serious chronic liver disease. Researchers will collect extensive samples—like blood, stool, and tissue—and perform various tests on about 143 adult participants with PSC over …

This study is creating a large collection of blood, saliva, stool, and other samples from people with rare liver diseases and healthy volunteers. The goal is to help researchers better understand diseases like Primary Sclerosing Cholangitis (PSC) and Primary Biliary Cholangitis (…

This study aims to understand the connection between gut bacteria and several chronic liver diseases. Researchers will compare blood and stool samples from 3,000 adult patients with conditions like autoimmune hepatitis and fatty liver disease to samples from their healthy househo…

This study aims to better understand primary sclerosing cholangitis (PSC), a rare disease that scars the liver's bile ducts. Researchers will observe 1,000 children and young adults (ages 2-25) who already have PSC, collecting health information, images, and samples over time. Th…