Primary biliary cholangitis (PBC)
Clinical trials for Primary biliary cholangitis (PBC) explained in plain language.
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Can a common cholesterol drug help manage a rare liver disease?
Disease control OngoingThis trial is testing the long-term safety of fenofibrate, a drug usually used for high cholesterol, in people with primary biliary cholangitis (PBC), a rare liver disease. The study involves 15 adults who have already completed a previous fenofibrate trial for PBC. Researchers a…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Early phase 1 • Sponsor: Xijing Hospital of Digestive Diseases • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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New hope for PBC: experimental drug CS0159 enters Mid-Stage trial
Disease control OngoingThis phase 2 study tests a new drug called CS0159 in 75 adults with primary biliary cholangitis (PBC), a chronic liver disease. Participants receive either CS0159 or a placebo for 12 weeks, followed by 40 weeks of open-label treatment. The goal is to see if CS0159 is safe and can…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase 2 • Sponsor: Cascade Pharmaceuticals, Inc • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New hope for Hard-to-Treat liver disease: steroid combo trial launches
Disease control By invitation onlyThis study looks at whether adding prednisone to standard UDCA treatment helps people with primary biliary cholangitis (PBC) who also have moderate to severe interface hepatitis, a type of liver inflammation. About 244 adults will be randomly assigned to receive either UDCA alone…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase 2/3 • Sponsor: Han Ying • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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New drug aims to lift fatigue and brain fog in liver disease patients
Symptom relief OngoingThis study tests a drug called golexanolone in 84 people with primary biliary cholangitis (PBC) who suffer from significant fatigue and cognitive problems. Participants receive either the drug or a placebo for up to 28 days. The goal is to see if the drug is safe and can improve …
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Phase 1/2 • Sponsor: Umecrine Cognition AB • Aim: Symptom relief
Last updated Aug 30, 2026 00:00 UTC
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Spanish databases used to map a rare liver disease
Knowledge-focused OngoingPrimary biliary cholangitis is a rare liver disease that slowly damages the bile ducts and can lead to cirrhosis or a liver transplant. Researchers are studying anonymised health records from about 3,000 adults in four Spanish databases to estimate how many people have the diseas…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Sponsor: Fundacio Privada Mon Clinic Barcelona • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Can a smartwatch help manage a rare liver disease? stanford study investigates
Knowledge-focused By invitation onlyThis study at Stanford University is testing whether wearable devices like smartwatches can help measure fatigue, sleep, and daily activity in people with primary biliary cholangitis (PBC), a chronic liver disease. Researchers will compare data from the wearables with patient que…
Matched conditions: PRIMARY BILIARY CHOLANGITIS (PBC)
Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC