PRIMARY BILIARY CHOLANGITIS (PBC)

This study tests a daily pill called elafibranor in adults with primary biliary cholangitis (PBC) who already have liver scarring (cirrhosis). The goal is to see if the drug can prevent the disease from getting worse, reducing the need for liver transplants and improving survival…

This study looks at the long-term safety of adding fenofibrate to standard ursodeoxycholic acid treatment for people with primary biliary cholangitis (PBC), a chronic liver disease. About 300 adults who have already completed a prior fenofibrate study will take the combination an…

This study is for adults with primary biliary cholangitis (PBC) who have not yet been treated. It compares the drug fenofibrate to the standard medicine, UDCA, to see which better helps the liver work normally. About 132 participants will take one of the two drugs daily for a yea…

This study looks at the long-term safety of combining fenofibrate with ursodeoxycholic acid in people with primary biliary cholangitis (PBC), a chronic liver disease. Researchers will monitor 150 participants for side effects and track outcomes like death, need for liver transpla…

This study looks for early signs of primary biliary cholangitis (PBC) in people who have a specific antibody (AMA) in their blood but normal liver enzyme levels (ALP). Researchers will perform a liver biopsy and special blood tests on 80 adults aged 18-80 to find factors that pre…

This study tests whether a non-drug program combining physical exercise, nutritional advice, and psychological support can reduce fatigue in people with primary biliary cholangitis (PBC). Researchers will enroll 64 adults with moderate to severe fatigue to see if the program impr…

This study is testing an experimental drug called golexanolone in people with primary biliary cholangitis (PBC) who struggle with severe fatigue and cognitive problems like brain fog. The trial has two parts: first, a short safety check in 84 adults, then a longer 28-day comparis…

This study aims to better understand primary biliary cholangitis (PBC), a chronic liver disease, in Chinese patients. Researchers will track 4,000 participants over time to see how symptoms like fatigue and itching affect their lives and how well treatments work. The goal is to i…

This study looks at 3,000 people with primary biliary cholangitis (PBC) to see if changes in a blood marker called alkaline phosphatase after treatment are linked to better survival without serious liver problems. Researchers will track participants over time to build a model tha…