Plexiform neurofibroma
Clinical trials for Plexiform neurofibroma explained in plain language.
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New drug cocktail aims to shrink NF1 tumors
Disease control Recruiting nowThis early-stage trial tests whether two cancer drugs, cabozantinib and selumetinib, can safely shrink plexiform neurofibromas in people aged 16 and older with neurofibromatosis type 1 (NF1). About 30 participants will receive the combination daily. The study first finds the safe…
Matched conditions: PLEXIFORM NEUROFIBROMA
Phase 1 • Sponsor: Girish Dhall, MD • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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New pill could shrink nerve tumors in NF1 patients
Disease control Recruiting nowThis study tests whether a new drug called TQ-B3234 can shrink non-surgical nerve tumors (plexiform neurofibromas) in adults with neurofibromatosis type 1 (NF1). About 177 participants will receive either the drug or a placebo. The main goal is to see if the drug reduces tumor si…
Matched conditions: PLEXIFORM NEUROFIBROMA
Phase 3 • Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Can a cancer drug stop nerve tumors before they cause harm?
Prevention Recruiting nowThis study tests whether giving selumetinib early to children with NF1, before nerve tumors cause symptoms, can prevent tumor growth and related problems. About 200 children aged 1 to 8 years with no known tumors will either receive the drug or be observed. The goal is to see if …
Matched conditions: PLEXIFORM NEUROFIBROMA
Phase 2 • Sponsor: University of Alabama at Birmingham • Aim: Prevention
Last updated Jun 27, 2026 13:00 UTC
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New study aims to map neurofibromatosis in russian adults
Knowledge-focused Recruiting nowThis study collects information from 200 adults in Russia who have neurofibromatosis type 1 (NF1) with plexiform neurofibromas. Researchers will look at patients' age, symptoms, and medical history to better understand the disease. No new treatments are being tested; the goal is …
Matched conditions: PLEXIFORM NEUROFIBROMA
Sponsor: AstraZeneca • Aim: Knowledge-focused
Last updated Aug 27, 2026 00:00 UTC
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New questionnaires could help NF1 patients voice appearance concerns
Knowledge-focused Recruiting nowThis study is developing questionnaires to measure how visible tumors in neurofibromatosis type 1 (NF1) affect patients' appearance concerns. About 110 participants, including children, adults, and caregivers, will complete surveys and join focus groups or interviews to give feed…
Matched conditions: PLEXIFORM NEUROFIBROMA
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC