PERIPHERAL VASCULAR DISEASES

This study tests whether using carbon dioxide gas instead of standard contrast dye during leg artery procedures can prevent serious kidney problems. About 1,960 people with blocked leg arteries and at moderate risk for kidney injury will be randomly assigned to receive either the…

This study is a large registry that will collect information from 5,000 people with peripheral vascular disease (narrowed arteries in the legs). It looks at how well Boston Scientific's drug-coated devices work in everyday medical practice, including in groups often left out of c…

This study tests two ways to help people with peripheral artery disease (PAD) walk farther and with less pain. It compares supervised treadmill exercise versus home walking, with or without nitrate-rich beetroot juice. The goal is to find a more convenient and effective treatment…

This study tests whether a single dose of the drug diroximel fumarate (Vumerity) can improve blood vessel function and walking ability in people with peripheral artery disease (PAD). PAD causes leg pain during walking due to poor blood flow. Researchers will give 20 participants …

This early-stage study tests whether fisetin, a compound found in fruits, can reduce aging-related cells in the body and improve walking ability in 34 people aged 50+ with peripheral artery disease (PAD). Participants will take fisetin or a placebo for several months, and researc…

This study looks at how different types of exercise affect blood vessel function in healthy people and those with PTSD or generalized anxiety disorder. Researchers will measure changes in blood flow and artery dilation. The goal is to understand if exercise can help improve vascu…

This study is not testing a new treatment. Instead, it gathers information on how well BALT medical devices work and how safe they are in everyday use for conditions like brain aneurysms, stroke, and blocked arteries. Up to 10,000 people will be included, and researchers will tra…

This study looks at how exercise affects blood vessel function in people with PTSD or generalized anxiety disorder compared to healthy individuals. Researchers want to understand if harmful substances in the blood called oxidants play a role in blood vessel damage. The study invo…

This study tests whether a computer alert system can help doctors remember to prescribe cholesterol-lowering medications to people with peripheral artery disease (PAD) who aren't currently taking them. About 400 adults with PAD will take part. The goal is to see if the alerts lea…

This study looks at how different types of exercise affect blood vessel function in healthy people and those with PTSD or generalized anxiety disorder. Researchers will measure changes in blood flow and artery dilation. The goal is to understand if exercise can help improve vascu…

This study looks at people with severe peripheral artery disease (blocked leg arteries). Researchers will use MRI scans before treatment to see which blockages are hard to cross and which tools cause the least damage to blood vessels. The goal is to learn how to make procedures s…