Pediatric obesity

This early-phase trial tests the drug phentermine/topiramate (Qsymia) in 13 adolescents aged 12-20 who have both obesity and type 2 diabetes. The drug is already approved for weight loss in adults. The study aims to see if it can safely lower body mass index (BMI) and improve blo…

This study tests whether a parent-only weight loss program followed by a family healthy lifestyles program works better than the family program alone. It involves 480 rural families with a child aged 6-11 who is overweight and a parent with a BMI between 25 and 50. The goal is to…

This study compares two approaches for treating type 2 diabetes in teenagers: weight-loss surgery (vertical sleeve gastrectomy) versus intensive medical therapy (including metformin and other drugs). The goal is to see which method provides better blood sugar control and reduces …

This study looks at whether a protein supplement called carnitine can reduce hardening of the arteries in teenagers at high risk for future heart disease. About 90 teens aged 11-21 with high triglycerides will take carnitine or a placebo. Researchers will measure artery stiffness…

Researchers are testing a 12-month physical activity program for adolescents with overweight. The program includes weekly 90-minute sessions with strength, endurance, and coordination training, plus a small-group session with peers. The study measures changes in fitness, strength…

This study tests a culturally tailored healthy eating program for Hispanic mothers and their children aged 7–12 in rural Arkansas. The program includes home lessons and cooking workshops to improve diet and cooking habits. Researchers will compare 16 mother-child pairs who get th…

This study tests a program called BasketballRx, which combines basketball activities with lessons on healthy eating, exercise, sleep, and stress management. The program is designed for teens aged 10 to 15 who are overweight or have obesity, and who identify as Black or Latino. Ov…

This study tests whether a 16-week family-focused lifestyle program can reduce type 2 diabetes risk in Latino children aged 10-16 who have obesity. The program includes nutrition education, behavior change skills, and physical activity. Researchers will measure glucose tolerance …

Project Viva is a long-term study that follows more than 2,000 mother-child pairs from pregnancy into the child's teenage years. Researchers measure children's growth, metabolic risk factors, and brain development, and they track mothers' weight and children's asthma symptoms. Th…

This study was designed to create a registry of medical information from children aged 1 to 18 with obesity. The goal was to collect historical and clinical data from medical charts to help researchers better understand pediatric obesity. However, the study was withdrawn before e…

This study follows 300 families with children aged 2 to 6 years over three years to understand how ongoing stress might lead to weight gain. Researchers will measure stress hormones and behaviors to see what role they play. The goal is to learn, not to test a treatment, so no new…

This study follows 180 children with overweight or obesity to see how their thinking skills (like memory and self-control) relate to eating habits and weight changes over time. Researchers will use brain tasks and interviews to understand these links. The goal is to find better w…

This study looks at whether digital health tools like text messages, videos, or AI conversations can improve the physical and mental health of middle school students. About 800 students aged 11 to 13, with normal weight, overweight, or obesity, will be split into four groups to c…