PANCREATIC NEUROENDOCRINE TUMOR

This study tests whether giving two chemotherapy drugs (capecitabine and temozolomide) after surgery can stop or delay high-risk pancreatic neuroendocrine tumors from coming back. About 141 participants will be randomly assigned to receive the drugs or just be watched. The goal i…

This study looks at people with stage 4 pancreatic neuroendocrine tumors (a rare, slow-growing cancer) that cannot be cured. It compares two approaches: near-total tumor removal surgery plus medical treatment versus medical treatment alone. The goal is to see if surgery helps pat…

This study compares two surgical methods for removing pancreatic or nearby tumors: laparoscopic (keyhole) surgery and open surgery. The goal is to see which approach has fewer complications and better outcomes. About 90 adults with resectable tumors will take part, and researcher…

This study tests a drug called belzutifan in people with certain rare or advanced cancers, including pheochromocytoma/paraganglioma, pancreatic neuroendocrine tumors, and tumors linked to von Hippel-Lindau disease. The goal is to see if the drug shrinks tumors or stops them from …

This early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer cells. The goal is to find a safe dose and see if t…

This early study tests a personalized mRNA vaccine (mRNA-0523-L001) in 21 adults with advanced endocrine tumors, such as adrenal, thyroid, or pancreatic cancers, that have not responded to standard treatments. The vaccine is designed to train the immune system to attack each pati…

This study tests an experimental drug called ESK981 in people with advanced pancreatic cancer, certain neuroendocrine tumors, or neuroendocrine prostate cancer. Participants take ESK981 capsules in a 5-days-on, 2-days-off cycle. The main goal is to see if the drug can keep the ca…

This study tests an artificial intelligence system that analyzes contrast-enhanced CT scans to help doctors decide the best course of action for people with suspected pancreatic diseases. The AI will classify patients into three groups: needing immediate treatment, close monitori…

This study is testing a new blood test that looks at DNA fragments to find pancreatic neuroendocrine tumors early and tell them apart from other pancreatic tumors. About 1,000 adults with certain pancreatic tumors will give blood samples before any treatment. The goal is to see h…