OVARIAN NEOPLASMS

This study is testing an experimental pill called LY3537982 for people with advanced cancers that have a specific genetic change called KRAS G12C. The research aims to find the safest and most effective dose, and see if the drug can shrink tumors in cancers like lung, colon, panc…

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have returned or spread. The therapy, called Tmod CAR T cells, is designed to find and kill cancer cells while trying to avoid harming the patient's healthy cells. Researchers…

This is the first study in people to test a new oral medication called NKT3964. The main goals are to find a safe dose and see if the drug shows early signs of shrinking tumors in adults with advanced cancers that have spread and no longer respond to standard treatments. The stud…

This early-stage study is testing a new radioactive drug called LY4337713 in adults with advanced cancers that have spread. The drug is designed to find and deliver radiation directly to cancer cells that have a specific marker called FAP. The main goals are to find a safe dose, …

This early-stage study is testing a new type of personalized cell therapy for people with advanced solid tumors, including mesothelioma, that have come back or spread after standard treatments. Doctors collect a patient's own immune cells, genetically modify them in a lab to bett…

This UK trial is testing if a drug combination already approved for breast cancer can help control other cancers with a specific genetic feature. It aims to treat adults and children (12+) with rare cancers or common cancers that have a rare genetic change called HER2. The goal i…

This study allows patients with ovarian or breast cancer who are already benefiting from the drug niraparib in previous trials to continue receiving it. The main goal is to monitor the long-term safety of continued treatment. Researchers will track side effects and health changes…

This trial is testing if a combination of two drugs, already approved for a type of skin cancer, can help control other rare cancers that share the same genetic change (a BRAF V600 mutation). It aims to enroll 30 adult patients with various rare or uncommon cancers to see if the …

This study is testing whether a new targeted drug called sacituzumab tirumotecan (Sac-TMT), given alone or with another drug called bevacizumab, can help people with advanced ovarian cancer live longer without their cancer getting worse. It compares these new maintenance treatmen…

This is a first-in-human study to test the safety and find the right dose of a new drug called PF-08046054/SGN-PDL1V for people with advanced solid tumors. It will be tested alone and in combination with another cancer drug, pembrolizumab. The study is recruiting 714 participants…

This study is testing a new drug called BMS-986340 to see if it is safe and can help control advanced cancers. It will be given alone or combined with two other cancer drugs to about 950 people whose cancers have grown despite standard treatments. The main goal is to find the rig…

This early-stage trial is testing an experimental drug called sigvotatug vedotin for people with advanced solid tumors that have spread or cannot be removed by surgery. The study will first determine safe doses, then test the drug alone and in combination with other cancer medica…

This large, two-part study is testing a new drug called sofetabart mipitecan for people with advanced ovarian, fallopian tube, or peritoneal cancer. Part A is for people whose cancer has stopped responding to standard platinum chemotherapy. Part B is for people whose cancer still…

This is the first study in people to test a new targeted cancer drug called LY4170156. It aims to find a safe dose and see if it can help control advanced cancers, including ovarian, lung, breast, and pancreatic cancers. The study will also test the drug in combination with other…

This is the first human study of an experimental cancer drug called DM002 for people with advanced solid tumors including ovarian, prostate, endometrial, and colorectal cancers. The study has two parts: first finding the safest dose, then testing that dose to see how well it work…

This study is developing a new test to detect ovarian cancer at an earlier, more treatable stage. Researchers will collect a uterine wash fluid sample and a blood sample from 250 women before they have surgery. They will analyze these samples to see if specific genetic and protei…

This study is testing a new type of ultrasound imaging to see if it can better evaluate growths on or near the ovaries. The goal is to improve the ability to tell if a growth is cancerous before a patient has surgery. Researchers will enroll 40 women who are already scheduled for…

This study is testing a less invasive method to check if early-stage ovarian cancer has spread to nearby lymph nodes. It compares a targeted 'sentinel node' technique against the standard, more extensive lymph node removal surgery. If successful, this new approach could mean fewe…

This study is testing a new communication tool designed to help patients with advanced ovarian cancer, their caregivers, and their doctors work together to set priorities for care during clinic visits. It is a pilot study to see if the tool is practical and acceptable to use. The…

This study is preparing for future cancer treatment trials by collecting information and materials from patients. Researchers will analyze tumor tissue from people with advanced solid tumors and collect their white blood cells through a procedure called apheresis. The collected c…

This study aims to understand why the immune system struggles to fight ovarian cancer. Researchers will collect blood, bone marrow, and tissue samples from 90 women—some with ovarian cancer and some without—to analyze their immune cells. The goal is to see if specific agents can …