ORAL CAVITY CANCER

This study tests a new surgical technique called the external pudendal flap (STEPA flap) for rebuilding the mouth or throat after cancer removal. The goal is to see if it causes fewer complications at the area where the flap is taken from. About 40 patients will be followed for a…

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink or control advanced head and neck cancer that has grown after initial therapy. About 40 adults whose cancer has spread or returned will receive the combination. The goal is to see how ma…

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform less extensive, function-preserving operations, reducing damage to swallowing, speech, and vision. The trial e…

This study looks at whether people with early-stage oral or throat cancer can have surgery and go home the same day, instead of staying in the hospital. It involves 25 patients and tracks how many need to be readmitted within 10 days. The goal is to make treatment more convenient…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study aims to see if a custom-made tumor culture system can predict how oral cavity cancer responds to the immunotherapy drug pembrolizumab before surgery. Twenty participants will provide a biopsy, receive pembrolizumab as standard care, and then have their tumor analyzed. …

This study looks at how cancer and its treatments change taste and smell, and how that affects eating habits and nutrition. Researchers will follow 306 people newly diagnosed with certain cancers (mouth, throat, colon, or liver) to see if sensory changes lead to undernutrition. T…

This study tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery, as guidelines recommend. About 532 adults with certain types of head and neck cancer will take part. The program uses patient navigators to guid…

This study tests whether using 3D computer models and printed surgical guides leads to better bone healing than standard free-hand surgery for people needing jaw reconstruction after oral cancer. About 420 adults will be randomly assigned to one of the two methods. The main goal …