NARCOLEPSY

This study looked at 155 adults with narcolepsy who switched from a high-sodium medication (sodium oxybate) to a low-sodium version (Xywav). The goal was to see if their blood pressure changed. The results could help doctors and patients choose the best treatment for managing nar…

This study looked at how LUMRYZ, a medicine for narcolepsy, works when used in regular medical practice. 71 adults with narcolepsy filled out questionnaires about their symptoms, treatment experience, and quality of life over 4 months. The main goal was to see if daytime sleepine…

This study tested a new once-nightly medication (FT218) for people with narcolepsy who experience excessive daytime sleepiness and sudden muscle weakness (cataplexy). The goal was to see if it is safe and tolerable over the long term, and whether people currently taking a twice-n…

This study tested the long-term safety and effectiveness of AXS-12 in 68 people with narcolepsy who experience sudden muscle weakness (cataplexy) and severe daytime sleepiness. Participants had already completed an earlier study of the same drug. The goal was to see if AXS-12 can…

This study tested a new delayed-release form of the drug pitolisant (called HBS-201) in 46 adults with narcolepsy. The main goal was to see if starting at a full therapeutic dose is tolerable, meaning few people stop treatment due to side effects. Researchers tracked how many par…

This study looked at how well people with narcolepsy or hypersomnia can drive while taking modafinil, a medication that promotes wakefulness. Twenty-seven licensed drivers who drove over 5,000 km per year took part. Researchers measured sleepiness and driving performance using a …

This study looked at 24 children (ages 6-17) with narcolepsy or hypersomnia to see if changes in their daily metabolism explain why they often gain weight and become obese. Researchers measured energy use at home and in the hospital using activity trackers. The goal was to uncove…