LYMPHOPROLIFERATIVE DISORDERS

This study tests if a stem cell transplant can cure people with severe immune system diseases. Participants receive healthy blood stem cells from a donor to rebuild their immune system. The study includes 66 people aged 4 to 69 who have not responded to standard treatments. The g…

This study tests a drug called alectinib, already approved for some lung cancers, in people with other rare cancers that have a specific gene change (ALK). About 30 adults, teens, and children will receive the drug to see if it shrinks tumors or stops cancer growth for at least 2…

This early-stage trial tests a new gene therapy called KLN-1010 for people with multiple myeloma that has come back or not responded to treatment. The therapy works by giving a single injection that instructs the body's own immune cells to become cancer-fighting cells (CAR-T cell…

This study tests atezolizumab, a drug already approved for some cancers, in people with rare cancers that have high tumor mutational burden (TMB), high microsatellite instability (MSI), or a specific DNA repair defect (CMMRD). About 30 adults, teens, and children will receive the…

This study tests the drug pacritinib in 100 people with T-cell lymphoma that has returned or not responded to prior therapy. The main goal is to see how many patients' tumors shrink or disappear. Participants will take the drug and be monitored for side effects and disease respon…

This study tests a drug called entrectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change (ROS1 fusion). About 30 adults and children with these rare tumors will receive the drug. Researchers will measure if tumors shrink …

This study tests a treatment called tabelecleucel for people who develop a rare, virus-linked cancer after an organ or stem cell transplant and whose cancer did not respond to standard therapy. About 115 participants will receive this cell therapy to see if it can shrink tumors a…

This study tests whether a stem cell transplant from a healthy donor can control peripheral T-cell lymphoma in patients whose cancer hasn't responded to standard treatments. Participants receive chemotherapy or antibody therapy before the transplant to prepare their body. The goa…

This study is testing whether a stem cell transplant from a healthy donor can safely treat people with severe immune system problems. Participants (ages 4-75) receive chemotherapy and then donor stem cells, followed by a hospital stay and years of monitoring. The goal is to see i…

This study tests an 8-week virtual rehab program (CaRE@Home) for cancer survivors who have finished treatment. It aims to reduce disability and improve physical function, anxiety, and quality of life. About 388 adults with breast, colorectal, head and neck cancer, or lymphoma wil…

This study is collecting blood, bone marrow, and tissue samples from over 1,000 people with blood cancers like leukemia and myeloma. Researchers will use advanced lab techniques to find unique markers (biomarkers) in each person's cancer. The goal is to better understand these di…

This study looks at blood cancer cells from 250 patients to understand which drugs might work best. Researchers will test many approved and experimental drugs on these cells in the lab. The goal is to find new treatment targets and match them to each patient's cancer type. This i…