LYMPHOPLASMACYTIC LYMPHOMA

This early-phase study tests a combination of two drugs, copanlisib and nivolumab, in people with certain types of blood cancer that have changed into a more aggressive form (Richter's transformation or transformed non-Hodgkin lymphoma). The goal is to find the best dose and see …

This study tests a new way to grow stem cells from umbilical cord blood to help people with high-risk blood cancers like leukemia and lymphoma recover faster after a bone marrow transplant. About 22 patients will receive the expanded stem cells along with standard chemotherapy an…

This study tests a two-drug combination (ixazomib and rituximab) in people with slow-growing B-cell non-Hodgkin lymphoma. The goal is to see how well the drugs shrink or control the cancer. About 33 adults with different types of this lymphoma are taking part.

This study tests an experimental radioactive drug called iopofosine I 131 in people with certain blood cancers (like Waldenstrom macroglobulinemia, multiple myeloma, and lymphoma) that have come back or not responded to standard treatments. The drug is designed to target and kill…

This early-stage study tests a DNA vaccine made from patients' own cancer cells to help their immune system fight lymphoplasmacytic lymphoma. Nine participants with asymptomatic disease received the vaccine to find the safest dose and see if it boosts immune response. The goal is…

This study looks at whether adding an oral medication (CC-486, or oral azacitidine) to a standard reduced-dose chemo regimen (R-miniCHOP) can help people aged 75 and older with newly diagnosed aggressive B-cell lymphomas. The goal is to see if the combination improves how long pa…

This study looks at how the 'watch and wait' approach affects the quality of life of people with slow-growing lymphomas. Researchers want to know if waiting without treatment causes anxiety or worry. About 250 Korean adults with these cancers will fill out questionnaires to measu…