LYMPHOPLASMACYTIC LYMPHOMA

This study tests a new drug called MDX2003 in adults with several types of B-cell lymphoma (like DLBCL or follicular lymphoma) that have returned or stopped responding to at least two prior treatments. The main goals are to find the safest dose and check if the drug can shrink tu…

This study compares three treatment approaches for people with previously untreated Waldenstrom's macroglobulinemia, a rare blood cancer. About 92 participants will receive either a combination of venetoclax and rituximab, or one of two other targeted therapies (ibrutinib plus ri…

This study tests a time-limited combination of three drugs (pirtobrutinib, venetoclax, and rituximab) in 40 adults newly diagnosed with Waldenström's macroglobulinemia, a rare blood cancer. The goal is to see if this treatment can achieve a very good partial response or better. P…

This early-phase study tests a new drug called SGR-1505 in about 98 adults with various B-cell blood cancers (like lymphoma and leukemia). The main goals are to check safety and find the best dose. Participants will receive the drug and be monitored for side effects and how the d…

This study tests a combination of two drugs, acalabrutinib and obinutuzumab, in people with untreated, slow-growing lymphomas like follicular lymphoma. The goal is to see if the combo can shrink tumors and control the disease. About 49 adults will take part, and researchers will …

This early-phase study tests whether a personalized cell therapy (CAR-T cells) is safe for people with certain types of Non-Hodgkin lymphoma that have come back or not responded to standard treatments. Up to 36 participants will receive their own immune cells that have been genet…

This study tests a drug called venetoclax in about 14 Japanese adults with a rare blood cancer (Waldenström macroglobulinemia) that has returned or stopped responding to prior therapy. Participants take venetoclax pills daily, with doses slowly increased to a target level. The ma…

This study tests a stem cell transplant from a half-matched donor for people with blood cancers. Before the transplant, patients receive chemotherapy and low-dose radiation to prepare the body. The goal is to see if this approach helps the new stem cells grow and fight cancer wit…

This study tests a drug called pacritinib in 30 people with Waldenström macroglobulinemia whose cancer returned or did not respond to prior treatment. The goal is to see if the drug can shrink tumors and improve symptoms. Participants take the drug by mouth and are monitored for …

This study follows up to 1,000 adults with certain blood cancers (CLL, SLL, LPL, or WM) to learn how these diseases change over time. Participants get regular check-ups, blood tests, and optional scans or biopsies, but no treatment is given. The goal is to better understand the d…