LOCALLY ADVANCED

This is the first study in people testing a new drug called AVZO-103 for advanced cancers that have spread. The main goals are to find a safe dose and see if the drug can shrink tumors in adults with advanced bladder cancer or other solid tumors. The study will test the drug alon…

This study is testing a new oral drug called REC-1245 for people with advanced cancers that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see if the drug can help shrink tumors. Participants will take the pill daily for up to two years.

This study is testing a new, one-time treatment for pancreatic cancer that cannot be removed by surgery. Doctors inject a radioactive 'glue' directly into the tumor to deliver targeted radiation, while patients continue their standard chemotherapy. The main goals are to see if th…

This study is testing a personalized treatment approach for people with locally advanced non-small cell lung cancer (NSCLC). It combines a new two-drug immunotherapy regimen (cemiplimab and fianlimab) with targeted radiation therapy. The goal is to see if this combination can bet…

This study is testing whether combining precise radiation therapy with a wearable device that creates electric fields around the tumor can slow the growth of locally advanced pancreatic cancer. All 48 participants will receive five days of targeted radiation while wearing the dev…

This study is testing whether a digital app that lets patients report their symptoms weekly helps doctors better manage side effects for people taking two cancer drugs (cabozantinib and nivolumab) for advanced kidney cancer. It involves 83 adults who are starting this specific dr…

This study is testing a new oral drug, PC14586 (rezatapopt), for people with advanced solid tumors that have a specific mutation in a gene called TP53 (Y220C). The main goals are to find a safe and effective dose and to see if the drug can shrink tumors. The trial is enrolling up…

This is the first human trial testing a new cancer drug called AVZO-1418. Researchers want to find the safest dose and see if it can shrink tumors in adults with advanced solid cancers that have spread or cannot be removed by surgery. The study will test the drug alone and possib…

This study is testing if a more precise, faster radiation treatment can better control advanced lung cancer that cannot be surgically removed. It will compare this new approach to the current standard method, both combined with chemotherapy and a year of immunotherapy. The main g…

This study is testing a more targeted approach to lymph node removal in patients with advanced breast cancer who have received chemotherapy before surgery. Researchers want to see if removing only specific marked lymph nodes (instead of many) can accurately determine whether canc…