LOCALLY ADVANCED

This study tests a new drug called AVZO-103 in people with advanced bladder cancer or other solid tumors that have spread. The drug is designed to attack cancer cells directly. The main goals are to check safety, find the best dose, and see if it shrinks tumors. About 355 adults …

This study tests a new way to give radiation therapy for stage III lung cancer that cannot be removed by surgery. It combines a smaller, faster radiation field with standard chemo and a follow-up immunotherapy drug called durvalumab. About 110 adults will be randomly assigned to …

This study tests whether a combination of two immunotherapy drugs (cemiplimab and fianlimab) plus radiation can shrink tumors in people with locally advanced non-small cell lung cancer who haven't had treatment before. About 76 participants will receive the drugs first, then radi…

This study tests a new drug called CUE-101, alone or with pembrolizumab, in 30 people with newly diagnosed, advanced HPV-16 head and neck cancer that cannot be removed surgically. The goal is to see if these treatments can boost the immune system to fight the cancer before standa…

This early study tests a new treatment called YntraDose™ for people with pancreatic cancer that cannot be removed by surgery. The treatment involves a one-time injection of a radioactive implant directly into the tumor, given alongside standard chemotherapy. The main goals are to…

This study tests a new drug called AVZO-1418 in people with advanced solid tumors that have spread. The main goals are to find a safe dose and see if the drug can shrink tumors. About 480 adults will take part in this first human trial.

This study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment will take the drug al…

This study tests whether weekly digital symptom reports from patients with advanced kidney cancer can help doctors make timely adjustments to their treatment with cabozantinib and nivolumab. About 83 adults starting this combination therapy will use a digital platform to report s…

This study tests an experimental daily pill, REC-1245, in people with advanced solid tumors or lymphomas that have not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors or control the disease. About 170 participants will take …

This study tests whether adding Tumor Treating Fields (TTF) to targeted radiation therapy can slow tumor growth in people with locally advanced pancreas cancer. Participants receive radiation for five days and use a wearable TTF device for at least 18 hours daily. The goal is to …

This study tests a special type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better and with fewer side effects than standard radiation. About 37 adults with advanced solid tumors will receive this tre…

This study looks at a less invasive technique called target axillary dissection (TAD) to check if cancer has spread to lymph nodes after chemotherapy in people with locally advanced breast cancer. The goal is to see if TAD is accurate enough to replace more extensive lymph node r…