LIVER DISEASES

This study looks at how well liver transplantation works for people with severe acute-on-chronic liver failure (ACLF). Researchers will track 3,000 adults with cirrhosis who are listed for a transplant to see who survives and how to improve outcomes. The goal is to find the best …

This study tests whether a minimally invasive procedure called endoscopic sleeve gastroplasty (ESG), which reduces stomach size by about 70%, can help people with obesity and a serious liver condition called MASH. Participants will be randomly assigned to receive either ESG plus …

This study tests a special clinic (Transitional Liver Clinic) for patients with advanced liver disease after they leave the hospital. The goal is to see if this clinic can reduce hospital readmissions within 30 days, improve quality of life, and boost patient satisfaction. About …

This study tests a method called normothermic machine perfusion, which keeps donated livers working outside the body so doctors can check their quality. The goal is to safely use livers that were previously considered unsuitable, helping 186 adults on the transplant waiting list …

This early-stage trial tests whether giving a mix of healthy gut bacteria to people hospitalized with liver disease is safe and tolerable. The bacteria come from healthy donors and are designed to restore missing gut microbes. 24 adults with liver failure or cirrhosis will receiv…

This study tests whether giving a drug called polyene phosphatidylcholine before and after laparoscopic liver surgery can reduce liver damage in people with liver cancer. About 96 adults will be split into two groups: one gets the drug combo, the other gets standard care. The mai…

This study tests a new treatment called RTX001 for people with severe liver cirrhosis that has caused complications. RTX001 uses the patient's own immune cells (macrophages) that are modified in a lab to reduce inflammation and scarring in the liver. The trial will enroll 30 adul…

This study is looking at whether a special MRI measurement of muscle health, called the muscle assessment score (MAsS), can help predict serious outcomes like death or the need for a liver transplant. Researchers will follow 1,200 adults with liver disease who are already schedul…

This study is testing two scoring systems (PLEASE and M10S20) to see if they can predict serious liver problems, including liver cancer, in 600 people with advanced chronic liver disease. Participants are split into two groups: one gets standard check-ups every six months, while …

This study looks at inflammation and healing markers in people with alcoholic liver disease. Researchers will compare three groups: those with alcoholic hepatitis, those with alcoholic cirrhosis, and healthy people without liver disease. The goal is to understand what drives seve…

This study aims to understand why some people with fatty liver disease develop a more serious form called NASH, which can lead to liver damage and cancer. Researchers will collect liver cells from 60 adults using a special needle and analyze them with advanced techniques. The goa…

This study is creating a large database of 2,000 people with metastatic liver cancer (cancer that has spread to the liver from another part of the body). Researchers will collect information on patients' health, treatments, and outcomes to learn more about the disease and how it …

This study enrolls people who have had liver damage from prescription drugs or herbal supplements. Researchers will collect health data and use special scans to track liver health over time. The goal is to better understand why some people get liver injury from these products. No…

This study looks at whether giving people with alcohol-related liver disease personalized options for alcohol treatment helps them actually start treatment and clears up any wrong ideas they may have. About 268 adults from University of Michigan clinics or hospitals will take par…

This study looks at the medical records of 15,000 people to understand how chronic liver diseases (like hepatitis, fatty liver, and cirrhosis) are connected to other health problems. Researchers will track who develops liver cancer or serious liver complications over time. The go…

This study is for Veterans with advanced liver disease. It tests a program where a nurse helps patients understand their illness, discuss what matters most to them, and explore options like a liver transplant or comfort care. The goal is to see if this approach helps more Veteran…

This study collects one-time blood or saliva samples from children who previously took part in liver disease research. The goal is to store their DNA for future studies on what causes these rare liver conditions, how they progress, and possible treatments. No new treatments are t…

This study looks at whether too much iron in the body raises the risk of liver problems in people who had a stem cell transplant more than 10 years ago. About 500 adults will be checked with blood tests and a special liver scan. The goal is to find out if treating iron overload c…

This study is testing a new single probe for FibroScan, a device that checks liver stiffness. Researchers want to see if this one probe works as well as the two different probes currently used. About 309 adults with chronic liver disease will take part. The goal is to simplify th…

This study follows 1,000 children with primary sclerosing cholangitis (PSC), a rare liver disease that damages bile ducts. Researchers will collect medical data, DNA, and other samples to understand how PSC progresses and affects daily life. The goal is to identify factors that m…