LEUKEMIA, MYELOID, ACUTE

This early-phase study tests a new drug called cusatuzumab, given alongside usual treatments, for adults with acute myeloid leukemia (AML) who cannot have strong chemotherapy. The main goal is to check the safety and side effects of this combination. About 61 participants will re…

This study tests two new drug combinations for adults newly diagnosed with a specific type of acute myeloid leukemia (AML) that has an IDH1 or IDH2 mutation. Participants receive either one of the targeted pills (AG-120 or AG-221) plus a standard shot (azacitidine), or azacitidin…

This study tests whether adding the targeted drug ivosidenib to standard azacitidine helps adults with a specific IDH1-mutated acute myeloid leukemia (AML) who are not healthy enough for strong chemotherapy. About 146 participants received either the combo or a placebo plus azaci…

This study tests an oral medication (azacitidine) as maintenance therapy for Chinese adults with acute myeloid leukemia who are in complete remission after chemotherapy. The goal is to see if the drug can help keep the cancer from returning longer than best supportive care alone.…

This early-stage study tests a new drug, JNJ-89853413, in about 64 adults whose acute myeloid leukemia or myelodysplastic neoplasms have returned or stopped responding to standard treatments. The main goals are to check safety, find the best dose, and see if the drug can help con…

This study tests whether adding the experimental drug cusatuzumab to two standard AML medications (venetoclax and azacitidine) helps people with newly diagnosed AML live longer. The trial includes 140 adults who cannot receive intensive chemotherapy. Researchers will compare surv…

This early-stage study tests a new drug called bleximenib combined with standard leukemia treatments for people with acute myeloid leukemia (AML) that has specific genetic changes (KMT2A or NPM1). The main goals are to find the best dose and check for side effects. About 196 part…

This study tests a program that combines mindfulness and music therapy, delivered through an app or website, to help people who are getting a stem cell transplant feel better and have a higher quality of life. About 60 adults with certain blood cancers will try the program during…

This study enrolls 120 people with different cancers who already received treatment in an earlier study. The goal is to track serious side effects and other health issues over time. No new treatment is given; participants are simply monitored for safety.