KIDNEY TRANSPLANT REJECTION

This early-stage study tests two drugs, carfilzomib and belatacept, along with standard steroids and immune-suppressing medicines, to treat a type of kidney transplant rejection called antibody-mediated rejection. The goal is to see if this combination is safe and can reduce harm…

This study tests whether the drug frexalimab can prevent kidney transplant rejection better than the standard drug tacrolimus. About 526 adults receiving their first kidney transplant will be randomly assigned to one of the two treatments and followed for up to 5 years. The main …

This study tests whether injecting special stem cells (from donated fat tissue) directly into the kidney's main artery is safe for people whose transplanted kidney is being rejected. It involves 12 adult kidney transplant recipients with signs of rejection on biopsy. The goal is …

This study tests whether adding a drug called tocilizumab to the usual treatment (IVIG, plasmapheresis, and rituximab) can better control chronic active antibody-mediated rejection (CAMR) in kidney transplant recipients. CAMR is a serious condition that often leads to kidney loss…

This study looks at whether changes in blood platelet function can signal kidney transplant rejection without needing a biopsy. Researchers will measure platelet activity in 60 adult kidney transplant recipients before and after surgery, and compare results with standard biopsy f…

This study is testing a new blood test called GraftAssureDx to see if it can detect kidney transplant rejection without needing a biopsy. About 125 kidney transplant recipients will provide blood and urine samples, and the test results will be compared to standard biopsy findings…

This study is testing whether a blood test (called DD-cfDNA) can accurately detect kidney transplant rejection, potentially replacing the need for invasive kidney biopsies. Researchers will compare the blood test results with standard biopsy analysis in 300 kidney transplant reci…

This study looks at whether a urine test for a protein called CXCL10 can spot kidney transplant rejection more accurately than current blood tests, especially when the blood test says everything is fine. Researchers will collect urine samples from 50 kidney transplant patients wh…

This study explores whether a special type of MRI, called manganese-enhanced MRI, can help identify people with kidney disease who are at risk for heart problems. Researchers will scan the heart and kidneys of 120 adults with various kidney conditions, including acute kidney inju…

This study tests whether a blood test that measures donor DNA can help doctors decide when a kidney biopsy is truly needed after a transplant. About 500 kidney transplant recipients will be randomly assigned to standard care or to have their doctors receive this blood test result…