Kidney failure

This pilot study tests whether using a cap containing chlorhexidine on dialysis catheters can reduce infections compared to standard caps. Sixty adults with kidney failure who need dialysis through a central line will be randomly assigned to one of the two caps. The main goal is …

This study tests a new wearable device that gently removes extra fluid between dialysis sessions. Many dialysis patients struggle with fluid buildup because standard treatments remove it too quickly, causing heart and brain damage. The device is worn at home for a few hours after…

This study tests whether cooling the dialysis fluid slightly can help preserve memory and thinking in people with kidney failure who need hemodialysis. Many patients on dialysis experience a decline in brain function, possibly due to drops in blood flow during treatment. The tria…

This study tests whether adding levocarnitine injections to standard care can lower the amount of anemia medication needed by people on hemodialysis. About 94 adults with kidney failure and anemia will receive either levocarnitine after each dialysis session or usual care alone f…

This trial tests a new drug called QRX3 in 3,000 people with chronic kidney disease whose kidney function is declining. The goal is to see if QRX3 can improve kidney function and slow the need for dialysis. Participants take QRX3 capsules, and researchers measure changes in kidne…

This study will test different methods to prevent infections and other problems from central lines (tubes placed in large veins) in 2,500 patients. It compares special antimicrobial caps and a skin anchor device against standard care. The goal is to find the best ways to keep pat…

Researchers are studying how the HIV combination pill Descovy, which contains tenofovir alafenamide and emtricitabine, moves through the bodies of people with HIV who also have advanced chronic kidney disease. About 50 adults with stage 3b or stage 4 kidney disease will take part…

This study follows 190 adults with chronic kidney disease who are not yet on dialysis. Over 24 months, researchers track clinical and lab measures to see who experiences a rapid drop in kidney function, defined as a sustained decline of more than 5 mL/min per year. The goal is to…

This study looks back at medical records of critically ill adults who needed emergency dialysis in the emergency department. It compares two methods—standard hemodialysis and a continuous version called CVVHDF—to see how patients fare during their hospital stay. The main focus is…

This study tests whether a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve how older adults (60+) are evaluated for kidney transplants. Fifty participants will either receive the KT-CGA plus usual care or usual care alone. The goal is to see if …