KIDNEY FAILURE

This study looks at how well the shingles vaccine (Shingrix) works and how safe it is in adults with kidney failure who are waiting for a kidney transplant. Some participants will get an extra dose of the vaccine after their transplant to see if it improves their immune protectio…

This study tests whether starting haemodialysis gradually (incremental dialysis) can help preserve quality of life and remaining kidney function in adults with kidney failure. About 372 people who are just beginning dialysis will take part. The goal is to see if this approach is …

This study tests a new device called the InnAVasc Arteriovenous Graft for people with end-stage kidney disease who need hemodialysis. The graft creates a connection between an artery and a vein to allow easy access for dialysis. The main goals are to see if the graft stays open a…

This study tests whether empagliflozin (Jardiance), a diabetes drug, can safely raise low sodium levels in patients with certain conditions like liver or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 days. The goal…

This study compares a special egg white pudding to a standard nutritional drink (Ensure Plus) in 54 adults with kidney failure who are on dialysis. The goal is to see if the pudding is a practical way to improve nutrition, blood protein levels, and frailty. Participants will rece…

This study tests a new liquid called Custodiol-N, used to preserve donated kidneys, livers, and pancreases before transplant. About 362 transplant recipients will take part. The goal is to see if this solution helps the organs work better right after surgery compared to the curre…

This early-phase study tests a treatment called Sip-Tego in 12 adults with kidney failure who need a living-donor kidney transplant. The goal is to see if the treatment can train the body to accept the new kidney without needing lifelong anti-rejection drugs. Participants will be…

This study tests a new approach using a patient's own modified immune cells (CAR T cells) to lower the risk of rejecting a donated kidney. It is for people with kidney failure who have been on the transplant waiting list for at least a year and have a very high chance of rejectin…

This study looks at whether starting peritoneal dialysis (a type of home dialysis) at a low dose and gradually increasing it is better than the standard full-dose approach. The goal is to see if this gentler start improves quality of life and reduces side effects. The trial invol…

This study looks at how a gene called APOL1 affects kidney transplant success. African Americans and others with recent African ancestry are more likely to have a risky version of this gene. Researchers will test DNA from 5000 donors and recipients to see if the gene leads to kid…

This study reviews medical records of about 10 adults who had a transplant and developed a difficult-to-treat CMV infection along with severe kidney disease or kidney failure. Researchers want to see how safe the drug maribavir is for these patients. The study does not change the…

This study looks at blood flow patterns in the kidneys and liver of adults admitted to the ICU after serious injuries. Researchers will use bedside ultrasound to check for abnormal patterns and see if they are linked to kidney failure or the need for a breathing machine. About 35…

This study looks at whether a home-based exercise program is safe and practical for adults aged 60 and older who are waiting for a kidney transplant. Participants will wear an activity tracker and may be assigned to online exercise classes or usual care. The goal is to see if the…