IgG4 related disease
Clinical trials for IgG4 related disease explained in plain language.
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Investigational drug AMG 335 offered to adults with IgG4-Related disease
Disease control ApprovedThis expanded access program allows adults with a confirmed diagnosis of IgG4-related disease to request the investigational drug AMG 335, also known as UPLIZNA. IgG4-related disease is a rare condition where the immune system causes inflammation and swelling in organs. The progr…
Matched conditions: IGG4 RELATED DISEASE
Sponsor: Amgen • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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New drug aims to shrink swollen glands in rare disease
Disease control OngoingThis study tests whether efgartigimod, a drug that lowers certain antibodies, can reduce swelling in the tear glands, saliva glands, or pancreas of people with IgG4-related disease. Five adults will receive weekly injections for 12 weeks and have regular scans and checkups. The g…
Matched conditions: IGG4 RELATED DISEASE
Phase 2 • Sponsor: Stanford University • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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New drug aims to stop Flare-Ups in rare autoimmune disease
Disease control OngoingThis study tests a drug called obexelimab to see if it can prevent flare-ups in people with IgG4-related disease, a rare condition where the immune system attacks the body's own tissues. About 194 adults with active disease will receive either the drug or a placebo. The main goal…
Matched conditions: IGG4 RELATED DISEASE
Phase 3 • Sponsor: Zenas BioPharma (USA), LLC • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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New drug aims to stop Flare-Ups in rare autoimmune disease
Disease control OngoingThis study tests a drug called inebilizumab to see if it can prevent flare-ups in people with IgG4-related disease, a rare condition that causes swelling and damage in organs. About 135 adults who have had recent flare-ups are taking part. The main goal is to see how long it take…
Matched conditions: IGG4 RELATED DISEASE
Phase 3 • Sponsor: Amgen • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC