Idiopathic hypersomnia

This trial tests whether a low-sodium form of oxybate, called XYWAV, can reduce daytime sleepiness and improve daily function in adults aged 18 to 75 with idiopathic hypersomnia or narcolepsy. Participants take the oral solution at night, with doses adjusted to their needs, and r…

This study tests whether clarithromycin, an antibiotic, can reduce excessive daytime sleepiness in people with narcolepsy or idiopathic hypersomnia. Participants receive either clarithromycin or a placebo for 14 days. Researchers will measure changes in sleepiness, brain activity…

This study looks at the long-term safety and effectiveness of pitolisant in adults with idiopathic hypersomnia, a condition causing excessive daytime sleepiness. Participants had already completed a previous study. The goal is to see if pitolisant remains safe and helps control s…

This study compares a new mass spectrometry technique to the standard radioimmunoassay for measuring orexin-A levels in cerebrospinal fluid. Orexin-A is a key brain chemical that is low in people with type 1 narcolepsy. The study involves 117 people with excessive daytime sleepin…

This study tests an oral drug called SDX (serdexmethylphenidate) to see if it safely reduces excessive daytime sleepiness in adults with idiopathic hypersomnia, a condition where people feel extremely sleepy during the day despite getting enough sleep at night. Participants will …

This study tested a once-nightly extended-release form of sodium oxybate (FT218) in 157 adults with idiopathic hypersomnia, a condition causing excessive daytime sleepiness despite adequate sleep. Participants were already on stable doses of stimulants or other alerting agents. T…

Idiopathic hypersomnia causes severe daytime sleepiness that differs from narcolepsy, yet researchers do not know what drives it. This study uses 64-electrode EEG to look for local slow waves, a sign of sleep-like activity in parts of an otherwise awake brain, while participants …

This study looks at the link between depression and hypersomnia—a condition causing excessive sleepiness. Researchers will monitor brain activity during sleep and measure reward function in 45 adults with idiopathic hypersomnia or hypersomnia linked to a psychiatric disorder. The…

This study tested a website designed to help teenagers with narcolepsy or idiopathic hypersomnia and their families understand and improve social relationships. Twenty-five teens and their parents reviewed the website's content, which included animations, patient stories, and exp…